Serial intravascular ultrasound evaluation of the DESolveTM novolimus-eluting bioresorbable coronary scaffold system
Catheter. cardiovasc. interv
; 92(6): 368-e374, Nov. 2018. tab, graf, ilus
Article
in English
| Sec. Est. Saúde SP, CONASS, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1223203
Responsible library:
BR79.1
ABSTRACT
INTRODUCTION:
Bioresorbable coronary scaffolds (BRS) have been developed to increase the late safety of coronary angioplasty by providing transitory coronary support and then being fully incorporated to the vessel wall. In the present trial, we sought to evaluate the performance and changes over time in the DESolveTM novolimus-eluting BRS using serial intravascular ultrasound (IVUS) in patients submitted to percutaneous coronary interventions.Methods:
Single-center, prospective, non-randomized study involving 17 consecutive patients submitted to implantation of the DESolveTM scaffold and serial evaluated with IVUS at different time points (post procedure, 6 and 18 months). Primary endpoint included the variation in lumen, scaffold, and vessel diameter and area along the months.RESULTS:
Angiographic success was achieved in all cases. Scaffold area and volume on IVUS were significantly greater at 6 months than at baseline (6.41 6 1.35 mm2 vs. 7.35 6 1.53 mm2, P < 0.002; and 101.19 6 20.9 mm3 vs. 118.51 6 26.6 mm 3, P 5 0.001). Late lumen loss was 0.22 6 0.30 mm at 6 months and 0.33 6 0.44 mm at 18 months. No major adverse cardiac events occurred. At late follow-up (18 months) the scaffold was not visualized by IVUS; therefore the evaluation was restricted to lumen and vessel at that time point.CONCLUSIONS:
IVUS serial evaluation of the novel DESolve BRS showed an increase in the device dimensions between baseline and 6 months, with concomitant enlargement of lumen dimensions and effective suppression of neointimal proliferation. At 18 months, no footprint of the scaffold was detected and the initial lumen enlargement was sustained.
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Collection:
National databases
/
Brazil
Database:
CONASS
/
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Main subject:
Angioplasty
/
Drug-Eluting Stents
/
Percutaneous Coronary Intervention
Type of study:
Controlled clinical trial
Language:
English
Journal:
Catheter. cardiovasc. interv
Year:
2018
Document type:
Article
Institution/Affiliation country:
Department of Invasive Cardiology, Instituto Dante Pazzanese de Cardiolog/BR
/
Department of Invasive Cardiology, Instituto Dante Pazzanese de Cardiologia/BR