Comparison of bacillary indexes in slit-skin smears, skin and nerve biopsies; a study from Malawi
Int. j. lepr. other mycobact. dis
; 65(2): 211-216, Jun. 1997. tab, graf
Article
in English
| Sec. Est. Saúde SP, HANSEN, Hanseníase Leprosy, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1226674
Responsible library:
BR191.1
Localization: [{"text": "BR191.1"}]
ABSTRACT
Data analyzed in this paper were collected within the framework of the Lepra Evaluation Project, an epidemiological study of leprosy in Karonga District, northern Malawi. For 212 patients information on the number of skin lesions, slit-skin smear and skin biopsy results were available. Among 61 patients with a single lesion none were slit-skin-smear positive and two had bacilli detected in skin biopsies. In contrast, among 119 patients with four or more lesions 34 (28.6%) versus 59 (49.6%) had bacilli detectable in slit-skin smears or skin biopsies, respectively. In a further 47 patients skin biopsy results could be compared with split-nerve biopsy results. In 20 of 47 patients the bacterial indexes (BIs) were identical in skin and nerve biopsies, while in 26 of 47 patients the BIs were higher in nerve than in skin biopsies. This difference, which is consistent with several other studies in the literature, provides an insight into the pathogenesis of leprosy.
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Leprosy
/
Neglected Diseases
Database:
HANSEN
/
Hanseníase Leprosy
/
Sec. Est. Saúde SP
/
SESSP-ILSLACERVO
Main subject:
Leprosy
/
Mycobacterium leprae
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Int. j. lepr. other mycobact. dis
Year:
1997
Document type:
Article
Institution/Affiliation country:
London School of Hygiene and Tropical Medicine/GB
/
Medical Research Council/GM
/
St. Thomas Hospital/GB