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No evidence of linkage between Mitsuda reaction and the NRAMP1 locus
Hatagima, Ana; Opromolla, Diltor Vladimir Araújo; Ura, Somei; Feitosa, Mary Furlan; Beiguelman, Bernardo; Krieger, Henrique.
Affiliation
  • Hatagima, Ana; Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Rio de Janeiro. BR
  • Opromolla, Diltor Vladimir Araújo; Secretaria de Esatdo da Saúde. Coordenadoria de Controle de Doenças. Instituto Lauro de Souza Lima. Bauru. BR
  • Ura, Somei; Secretaria de Esatdo da Saúde. Coordenadoria de Controle de Doenças. Instituto Lauro de Souza Lima. Bauru. BR
  • Feitosa, Mary Furlan; Washington University School of Medicine. Division of Biostatistics. St. Louis. US
  • Beiguelman, Bernardo; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
  • Krieger, Henrique; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
Int. j. lepr. other mycobact. dis ; 69(2): 99-103, Jun., 2001. tab
Article in English | Sec. Est. Saúde SP, HANSEN, Hanseníase Leprosy, SESSP-ILSLACERVO, Sec. Est. Saúde SP | ID: biblio-1227008
Responsible library: BR191.1
Localization: [{"text": "BR191.1"}]
ABSTRACT
Thirty sib-pairs were ascertained through unrelated lepromatous probands. They consisted of 22 healthy individuals and 8 leprosy patients. The Mitsuda reactions of all sibs were evaluated both macroscopically and histologically, and high molecular weight genomic DNA was extracted from the white blood cells of all sib-pairs. Three DNA polymorphisms identified by polymerase chain reaction (274C/T, D543N, 1729 + 55del4) were used as chromosome markers at the NRAMP1 locus. Sib-pair comparisons did not disclose any sign of close linkage between the Mitsuda reaction and the genetic markers.
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Full text: Available Collection: National databases / Brazil Health context: Neglected Diseases Health problem: Leprosy / Neglected Diseases Database: HANSEN / Hanseníase Leprosy / Sec. Est. Saúde SP / SESSP-ILSLACERVO Main subject: Lepromin Type of study: Evaluation study Language: English Journal: Int. j. lepr. other mycobact. dis Year: 2001 Document type: Article Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Secretaria de Esatdo da Saúde/BR / Universidade de São Paulo/BR / Washington University School of Medicine/US
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Full text: Available Collection: National databases / Brazil Health context: Neglected Diseases Health problem: Leprosy / Neglected Diseases Database: HANSEN / Hanseníase Leprosy / Sec. Est. Saúde SP / SESSP-ILSLACERVO Main subject: Lepromin Type of study: Evaluation study Language: English Journal: Int. j. lepr. other mycobact. dis Year: 2001 Document type: Article Institution/Affiliation country: Fundação Oswaldo Cruz/BR / Secretaria de Esatdo da Saúde/BR / Universidade de São Paulo/BR / Washington University School of Medicine/US