Use of genetic profiling in leprosy to discriminate clinical forms of the disease
s.l; s.n; Sep. 2003. 4 p. graf.
Non-conventional
in English
| Sec. Est. Saúde SP, HANSEN, Hanseníase Leprosy, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1240972
Responsible library:
BR191.1
Localization: [{"text": "BR191.1", "_a": "09142/s"}, {"text": "BR191.1", "_a": "09145/s"}]
ABSTRACT
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.
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Collection:
National databases
/
Brazil
Health context:
Neglected Diseases
Health problem:
Leprosy
/
Neglected Diseases
/
Tuberculosis
Database:
HANSEN
/
Hanseníase Leprosy
/
Sec. Est. Saúde SP
/
SESSP-ILSLACERVO
Main subject:
Membrane Glycoproteins
/
Receptors, Immunologic
/
Colony Count, Microbial
/
Leprosy, Lepromatous
/
Leprosy, Tuberculoid
/
Cluster Analysis
/
Gene Expression Regulation
/
Polymerase Chain Reaction
/
Cytokines
/
Macrophages, Alveolar
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Year:
2003
Document type:
Non-conventional