Quercetin modulates age-induced changes in the transcript levels of some apoptosis related genes in the skeletal muscles of male rats
Braz. J. Pharm. Sci. (Online)
; 56: e18861, 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1249162
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Adverse changes occur gradually in the skeletal muscles with age via continuous exposure to oxidative stress. Quercetin, a member of the flavonoids family, possesses anti-oxidative and radical-scavenging activities. Therefore, this study investigated the role of quercetin to modulate age-induced changes in the transcript levels of some apoptosis-related genes in rat's gastrocnemius muscles, up to 15 months-old. Half of the rats at each age (1, 5, 10 and 15 months old) were given a vehicle and the other half was given 200 mg/kg quercetin for 2 weeks, respectively. With the increase of age, vehicle groups showed hyalinization of the muscle fibers and a decrease of the catalase and an increase of the malondialdehyde levels. Down-regulation of Bcl2 gene and up-regulation of both NF-κB and Bax genes were recorded. Interestingly, quercetin groups showed focal hyalinization of the muscle fibers at both 10th and 15th months old. An increase in the catalase and a decrease in malondialdehyde levels, up-regulation of Bcl2 gene and down-regulation of both NF-κB and Bax genes were recorded. In conclusion, quercetin minimized age-induced alteration in the morphological structure and the expression of the apoptosis-related genes via increasing the antioxidant defense in the gastrocnemius muscle.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Role
/
Apoptosis
/
Muscle, Skeletal
/
Muscles
Limits:
Animals
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2020
Document type:
Article
Affiliation country:
Egypt
Institution/Affiliation country:
Tanta University/EG