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Laboratory diagnosis of human T-lymphotropic virus in Brazil: assays, flowcharts, challenges, and perspectives
Caterino-de-Araujo, Adele; Barbosa-Stancioli, Edel Figueiredo; Alonso Neto, José Boullosa; Aragón, Mayra Gonçalves; Galvão-Castro, Bernardo; Ishak, Ricardo; Rosadas, Carolina.
Affiliation
  • Caterino-de-Araujo, Adele; Instituto Adolfo Lutz. Centro de Imunologia. Laboratório de Pesquisa em HTLV. São Paulo. BR
  • Barbosa-Stancioli, Edel Figueiredo; Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Virologia Básica e Aplicada. Belo Horizonte. BR
  • Alonso Neto, José Boullosa; Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis. Brasília. BR
  • Aragón, Mayra Gonçalves; Universidade Federal do Espírito Santo. Programa de Pós-Graduação em Doenças Infecciosas. Vitória. BR
  • Galvão-Castro, Bernardo; Escola Bahiana de Medicina e Saúde Pública. Centro Integrativo e Muldisciplinar de Atendimento ao Portador de HTLV. Salvador. BR
  • Ishak, Ricardo; Universidade Federal do Pará. Instituto de Ciências Biológicas. Laboratório de Virologia. Belém. BR
  • Rosadas, Carolina; Imperial College Healthcare NHS Trust. St. Marys Hospital. National Centre for Human Retrovirology. London. GB
Rev. Soc. Bras. Med. Trop ; 54: e01752021, 2021. tab, graf
Article in English | LILACS | ID: biblio-1250822
Responsible library: BR1.1
ABSTRACT
Abstract INTRODUCTION We present a data analysis and review of recent studies regarding the laboratory diagnosis of human T-lymphotropic virus 1 and 2 (HTLV-1/2) infections in Brazil. METHODS Target populations, available diagnostic serological assays (screening and complementary tests), molecular assays (in-house), causes of false-positive and false-negative results, and flowcharts were analyzed. RESULTS A table presents the target populations, two diagnostic flowcharts (depending on laboratory infrastructure and study population), and recent research that may improve how HTLV-1/2 is diagnosed in Brazil.

CONCLUSIONS:

Our results support the implementation of public policies to reduce HTLV-1/2 transmission and its associated diseases.
Subject(s)

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Full text: Available Collection: International databases Database: LILACS Main subject: Human T-lymphotropic virus 1 / HTLV-I Infections / HTLV-II Infections / Clinical Laboratory Techniques Type of study: Diagnostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Document type: Article Affiliation country: Brazil / United kingdom Institution/Affiliation country: Escola Bahiana de Medicina e Saúde Pública/BR / Imperial College Healthcare NHS Trust/GB / Instituto Adolfo Lutz/BR / Ministério da Saúde/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal do Espírito Santo/BR / Universidade Federal do Pará/BR
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Full text: Available Collection: International databases Database: LILACS Main subject: Human T-lymphotropic virus 1 / HTLV-I Infections / HTLV-II Infections / Clinical Laboratory Techniques Type of study: Diagnostic study Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Rev. Soc. Bras. Med. Trop Journal subject: Tropical Medicine Year: 2021 Document type: Article Affiliation country: Brazil / United kingdom Institution/Affiliation country: Escola Bahiana de Medicina e Saúde Pública/BR / Imperial College Healthcare NHS Trust/GB / Instituto Adolfo Lutz/BR / Ministério da Saúde/BR / Universidade Federal de Minas Gerais/BR / Universidade Federal do Espírito Santo/BR / Universidade Federal do Pará/BR