Infusion of convalescent plasma is associated with clinical improvement in critically ill patients with Covid-19: a pilot study
Rev. invest. clín
; 72(3): 159-164, May.-Jun. 2020. tab, graf
Article
in English
| LILACS
| ID: biblio-1251850
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Background:
The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed.Objective:
The objective of the study was to study the safety and outcomes of the administration of CoPla to individuals with severe COVID-19 in an academic medical center.Methods:
Ten patients were prospectively treated with plasma from COVID-19 convalescent donors.Results:
Over 8 days, the sequential organ failure assessment score dropped significantly in all patients, from 3 to 1.5 (p = 0.014); the Kirby index (PaO2/FiO2) score increased from 124 to 255, (p < 0.0001), body temperature decreased significantly from 38.1 to 36.9°C (p = 0.0058), and ferritin levels also dropped significantly from 1736.6 to 1061.8 ng/ml (p = 0.0001). Chest X-rays improved in 7/10 cases and in 6/10, computerized tomography scans also revealed improvement of the lung injury. Decreases in C-reactive protein and D-dimer levels were also observed. Three of five patients on mechanical ventilation support could be extubated, nine were transferred to conventional hospital floors, and six were sent home; two patients died. The administration of CoPla had no side effects and the 24-day overall survival was 77%.Conclusions:
Although other treatments were also administered to the patients and as a result data are difficult to interpret, it seems that the addition of CoPla improved pulmonary function.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.3 End transmission of communicable diseases
Health problem:
Pneumonia
Database:
LILACS
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Betacoronavirus
Type of study:
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. invest. clín
Journal subject:
Medicine
Year:
2020
Document type:
Article
Affiliation country:
Mexico
Institution/Affiliation country:
Clínica Ruiz/MX
/
Hospital Puebla/MX
/
Hospital Ángeles de Puebla/MX
/
Universidad Popular Autónoma del Estado de Puebla/MX