Studies of anticancer and antipyretic activity of Bidens pilosa check for this species in other resources whole plant
Afr. health sci. (Online)
; 6(1): 27-30,
Article
in English
| AIM (Africa)
| ID: biblio-1256448
Responsible library:
CG1.1
ABSTRACT
Screening of different extracts and fractions from the plant Bidens pilosa check for this species in other resources Linn. var. (Asteraceae) has been conducted using the in - vitro comet assay for anticancer and the antipyretic action; which was done with in - vivo models.The extract from whole plant was extracted with n - hexane;chloroform and methanol extract (E1 - E3).The extracts were fractioned by column chromatography method and fractioned with ethyl acetate; acetone and water (F1 - F3).All the extracts and fractions were tested for anticancer and antipyretic activity. Among extracts E1 shows remarkable anticancer activity and E3 bears maximum antipyretic activity. In the antipyretic activity; paracetamol was used as the standard test drug.The most promising material (LC50 1500 ?g / ml) was F1 ethyl acetate fractions of methanolic extract and methanolic crude extract of whole plants. However; little correlation was observed in the degree of antipyretic activity between the test drug and standard drug. In conclusion; the extract obtained from the whole plant of Bidens pilosa showed a significant cytotoxic effect to methanolic extract against Hela cells by in vitro method and showed a comparable antipyretic activity effect to paracetamol in rabbit pyrogen test
Full text:
Available
Database:
AIM (Africa)
Main subject:
Plants
/
Comet Assay
/
Bidens
/
Analgesics
/
Neoplasms
Language:
English
Journal:
Afr. health sci. (Online)
Document type:
Article