Non-Adherence to Anti-TB Drugs among TB/HIV Co-Infected Patients in Mbarara Hospital Uganda: Prevalence and Associated Factors
Afr. health sci. (Online)
; 9: 8-15, 2009.
Article
in English
| AIM (Africa)
| ID: biblio-1256523
Responsible library:
CG1.1
ABSTRACT
Background:
Non-adherence to treatment remains a major obstacle to efficient tuberculosis control in developing countries. The dual infection of Tuberculosis and HIV presents further adherence problems because of high pill burden and adverse effects. This poses a risk of increased multi-drug resistant TB. However; the prevalence of non-adherence and its associated factors have not been studied in these patients in Uganda.Objectives:
To determine the prevalence and factors associated with non-adherence to anti-TB drugs among TB/HIV co-infected patients in Mbarara hospital.Methods:
A cross-sectional study with qualitative and quantitative data collection methods was conducted among TB/HIV co-infected adults in Mbarara hospital from January to March 2008. Consecutive sampling was used to select 140 participants. Adherence was assessed over a 5-day period prior to the interview using patients self-reports. Data was collected using an interviewer administered questionnaire. Qualitative data was collected through key informant interviews using a topic guide and was analyzed manually. Quantitative data was analyzed using STATA version 8. Logistic regression was used to determine factors associated with non-adherence.Results:
The prevalence of non-adherence was 25(95CI=17.8-32). Being on continuous phase of the TB regimen was significantly associated with non-adherence (OR=6.24; p0.001). Alcohol consumption; being on antiretroviral therapy and smoking confounded the relationship between stage of the TB regimen and non-adherence.Conclusion:
The prevalence of non-adherence was high. Patients that are on continuous phase of TB treatment should be supported to continue taking their drugs. In addition; patients that drink alcohol; smoke and those not on ART should be targeted with interventions to improve adherence
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Neglected Diseases
/
Tuberculosis
Database:
AIM (Africa)
Main subject:
HIV Infections
/
Medication Adherence
/
Antitubercular Agents
Type of study:
Observational study
/
Prevalence study
/
Qualitative research
/
Risk factors
Language:
English
Journal:
Afr. health sci. (Online)
Year:
2009
Document type:
Article