Successful Treatment of Homozygous Cystinuria with Captopril
Afr. j. urol. (Online)
; 13(2): 119-123, 2007.
Article
in En
| AIM
| ID: biblio-1258052
Responsible library:
CG1.1
ABSTRACT
Objective:
Cystinuria is an autosomal recessive hereditary disorder associated with nephrolithiasis and its attendant complications. Traditional management using oral alkali; D-penicillamine; or mercaptopropionyglycine in an attempt to increase urinary cystine solubility is often unsuccessful due to intolerable side-effects. The aim of this study was to determine; if captopril could reduce urinary cystine excretion in homozygous cystinuric patients. Patients andmethods:
Three cystinuric patients with a history of multiple cystine stones despite previous traditional therapy were treated with 150 mg captopril daily for 3 years after determination of their baseline 24-hour urine cystine excretion. Cystine excretion studies were repeated subsequently at 6-month intervals.Results:
The baseline 24-hour urine cystine excretion was within the expected limits for homozygous cystinuria in all patients (1072; 862 and 959 mg cystine per gm creatinine per 24 hours). After institution of captopril treatment; all patients had a significant decrease in urinary cystine levels (374; 313 and 451 mg cystine per gm creatinine per 24 hours). No patient experienced recurrent nephrolithiasis or adverse drug effects.Conclusion:
We conclude that captopril can significantly decrease urinary cystine excretion in patients with homozygous cystinuria. Captopril should be considered an alternative to traditional drug management of cystinuria
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Database:
AIM
Main subject:
Calculi
/
Captopril
/
Lithiasis
/
Cystinuria
Language:
En
Journal:
Afr. j. urol. (Online)
Year:
2007
Document type:
Article