Lack of efficacy of the standard potency Edmonston-Zagreb live, attenuated measles vaccine in African infants
Bull. W.H.O. (Online)
; 69(2): 221227-1991. ilus
Article
in English
| AIM (Africa)
| ID: biblio-1259777
Responsible library:
CG1.1
ABSTRACT
The efficacy of standard potency Edmonston-Zagreb (E-Z) measles vaccine was tested in a randomized trial of Black infants in a rural area of South Africa where a measles epidemic was occurring. The following immunization schedules were used 48 infants aged 4-8.5 months who received 3.9 log 50 infectious units of E-Z vaccine (group A); 48 infants aged 4-8.5 months who received 3.28 log 50 infectious units of Schwarz vaccine (group B); and 28 infants aged greater than 9 months who received 3.28 log 50 infectious units of Schwarz vaccine and served as controls (group C). For infants aged less than 23 weeks who were given either the E-Z or Schwarz vaccine, the number of seropositives was low (28%), irrespective of the pre-vaccination level of measles antibody. There was a higher number of seropositives (68%) among those in the age range greater than 23 weeks to less than 36 weeks who received the E-Z vaccine rather than the Schwarz vaccine (36%). When administered to children aged greater than 36 weeks, the Schwarz vaccine produced a satisfactory, though suboptimal response rate (61%). There was no correlation between seropositivity and pre-vaccination measles antibody status. Use of the standard dose of E-Z vaccine may have been one of the factors for this poor response, and this supports the WHO recommendation that titres higher than the standard potency vaccine are needed if 6-month-old infants are to be successfully immunized against measles
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
AIM (Africa)
Main subject:
South Africa
/
Immunoglobulin G
/
Measles Vaccine
/
Seroepidemiologic Studies
/
Immunoglobulin Allotypes
/
Measles
Type of study:
Controlled clinical trial
Country/Region as subject:
Africa
Language:
English
Journal:
Bull. W.H.O. (Online)
Year:
1991
Document type:
Article