The effect of chloroquine on rat liver cytochrome P-450 is mediated at the level of transcription

ABSTRACT

This paper looks at the effects of chloroquine administration on the turnover of rat liver cytochrome P-450 mRNA. It is suggested from this work that the effect of chloroquine on rat liver cytochrome P-450 is mediated at the level of transcription. It was noted from these studies that there was a marked decrease in the yield of membrane-bound polysomes from chloroquine-treated rats