Effects of hydrosalpinx on endometrial implantation failures: evaluating salpingectomy in women undergoing in vitro fertilization / Efeitos do hydrosalpinx no falho de implantação endometrial: Avaliar a salpingectomia nas mulheres em curso de fertilização in vitro
Rev. bras. ginecol. obstet
; 43(4): 304-310, Apr. 2021. graf
Article
in English
| LILACS
| ID: biblio-1280037
Responsible library:
BR1.1
ABSTRACT
Abstract Hydrosalpinx is a disease characterized by the obstruction of the salpinx, with progressive accumulation in the shape of a fluid-filled sac at the distal part of the tuba uterina, and closed to the ovary. Women with hydrosalpinges have lower implantation and pregnancy rates due to a combination of mechanical and chemical factors thought to disrupt the endometrial environment. Evidence suggests that the presence of hydrosalpinx reduces the rate of pregnancy with assisted reproductive technology. The main aim of the present is review to make an overview of the possible effects of hydrosalpinx on in vitro fertilization (IVF).We conducted a literature search on the PubMed, Ovid MEDLINE, and Google Scholar data bases regarding hydrosalpinx and IVF outcomes. Hydrosalpinx probably has a direct toxic effect on sperm motility and on the embryos. In addition, the increasing liquid inside the salpinges could alter the mechanisms of endometrial receptivity. The window of endometrial receptivity is essential in the implantation of blastocysts, and it triggers multiple reactions arising from the endometrium as well as the blastocysts. Hydrosalpinx could influence the expression of homeobox A10 (HOXA10) gene, which plays an essential role in directing embryonic development and implantation. Salpingectomy restores the endometrial expression of HOXA10; therefore, it may be one mechanism by which tubal
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Embryo Implantation
/
Fertilization in Vitro
/
Treatment Failure
/
Fallopian Tube Diseases
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Salpingectomy
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Infertility, Female
Type of study:
Etiology study
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Rev. bras. ginecol. obstet
Journal subject:
Gynecology
/
Obstetrics
Year:
2021
Document type:
Article
Affiliation country:
Italy
/
United States
Institution/Affiliation country:
Clinica Valle Giulia/IT
/
Università Campus Bio-Medico/IT
/
Università degli Studi della Campania Luigi Vanvitelli/IT
/
Università degli Studi di Firenze/IT
/
Yale School of Medicine/US