Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil
Braz. J. Pharm. Sci. (Online)
; 57: e18479, 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1339305
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
The seed oil of Annona salzmannii A. DC. was analyzed by GC-MS and 1H qNMR, revealing a mixture of unsaturated (80.5%) and saturated (18.7%) fatty acids. Linoleic (45.3%) and oleic (33.5%) acid were the major unsaturated fatty acids identified, while palmitic acid (14.3%) was the major saturated fatty acid. The larvicidal effects of A. salzmannii seed oil were evaluated against third-instar larvae of Aedes aegypti (Linn.). The oil exhibited moderate larvicidal activity, with a LC50 of 569.77 ppm (95% CI = 408.11 to 825.88 ppm). However, when the cytotoxic effects of the oil were evaluated, no expressive antiproliferative effects were observed in tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia), HL-60 (human promyelocytic leukemia), and non-tumor cell line PBMC (peripheral blood mononuclear cells), with IC50 values > 50 µg·mL-1. This is the first study to evaluate the chemical composition, larvicidal and cytotoxic activity of A. salzmannii seed oil
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Seeds
/
Plant Oils
/
Annonaceae
/
Annona
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2021
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Amazonas/BR
/
Federal University of Paraná/BR
/
Federal University of Sergipe/BR
/
Oswaldo Cruz Foundation/BR