Late vitamin K deficiency bleeding in infants: five-year prospective study
J. pediatr. (Rio J.)
; 97(5): 514-519, Sept.-Oct. 2021. tab, graf
Article
in English
| LILACS
| ID: biblio-1340159
Responsible library:
BR1.1
ABSTRACT
Abstract Objective:
To study the presenting clinical and demographic features, risk factors, and outcome of infants with late vitamin K deficiency bleeding.Methods:
Over a 5-year study period, the presenting clinical features and outcome of all 47 infants observed aged less than 6 months, who were diagnosed with late-onset primary and secondary VKDB by detailed history, physical examination, and laboratory findings were evaluated. Confirmed primary late VKDB was diagnosed when no cause other than breastfeeding could be found, while in the secondary subtype additional risk factors compromising the vitamin K effect were diagnosed.Results:
Secondary late VKDB (83%, 39 patients) was more common than the primary subtype. The mean age of patients was 10.50 ± 5.75 and 9.74 ± 6.04 weeks in primary and secondary VKDB subtypes, respectively, and the age of infants did not have a significant difference (> 0.05). The male to female ratio was 2.131. The residency, place and mode of delivery, gestational age, and types of feeding of patients did not have a significant difference between VKDB subtypes. The skin and gastrointestinal tract (GIT) (40.4%) followed by intracranial hemorrhage (ICH) (32%), were common sites of bleeding. Neurological complications were seen in 21% of patients; however, lethality was 23%, and the outcome of patients did not have a significant difference (p > 0.05) between VKDB subtypes.Conclusion:
Secondary late VKDB is more common than the primary subtypes, and late VKDB is still a serious disease in developing countries, including Iraq, when vitamin K prophylaxis isn't routinely used at birth.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Vitamin K Deficiency Bleeding
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
English
Journal:
J. pediatr. (Rio J.)
Journal subject:
Pediatrics
Year:
2021
Document type:
Article
Affiliation country:
Iraq
Institution/Affiliation country:
University of Misan/IQ