Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome
Rev. Assoc. Med. Bras. (1992, Impr.)
; 67(8): 1124-1129, Aug. 2021. tab
Article
in En
| LILACS
| ID: biblio-1346965
Responsible library:
BR1.1
ABSTRACT
SUMMARY OBJECTIVE Recent studies have linked malnutrition with undesirable outcomes in cardiovascular diseases. However, the underlying mechanism is unknown. Contrast-induced acute kidney injury (CI-AKI) increased cardiovascular mortality after percutaneous coronary intervention (PCI). This study hypothesizes that prognostic nutritional index (PNI) plays a role in the development of CI-AKI in patients with acute coronary syndrome undergoing emergency PCI. METHODS This study enrolled 551 patients. PNI was determined as 10× serum albumin (g/dL)+0.005×total lymphocyte count (mm3). CI-AKI was characterized as the increase in serum creatinine ≥0.3 mg/dL level within 48 h after PCI. Patients were classified as either CI-AKI (+) or CI-AKI (−). RESULTS CI-AKI has occurred in 72 of 551 patients (13.1%). PNI was significantly lower in the CI-AKI (+) group than in the CI-AKI (-) group (44.4±6.6 versus 47.2±5.8, p<0.001, respectively). Multivariate logistic regression analysis showed that PNI [odds ratio, OR 1.631, 95% confidence interval (CI) 1.168-2.308, p=0.02] and estimated glomerular filtration rate (OR 3.26, 95%CI 1.733-6.143, p<0.001) were independent risk factors for CI-AKI. CONCLUSIONS PNI is an independent risk factor for CI-AKI. The development of CI-AKI may be the mechanism responsible for the relationship between poor nutritional status and adverse cardiac events.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Acute Coronary Syndrome
/
Acute Kidney Injury
/
Percutaneous Coronary Intervention
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
MEDICINA
Year:
2021
Document type:
Article
Affiliation country:
Turkey
Country of publication:
Brazil