Oropharyngeal colostrum immunotherapy and nutrition in preterm newborns: meta-analysis
Rev. saúde pública (Online)
; 55: 1-11, 2021. tab, graf
Article
in English
| LILACS, BBO - Dentistry
| ID: biblio-1352195
Responsible library:
BR1.1
ABSTRACT
ABSTRACT OBJECTIVE To investigated the effect of oropharyngeal colostrum immunotherapy in reducing the time required for very low birth weight preterm newborns (VLBW-PTNB < 1,500g and < 37 weeks) to achieve full enteral nutrition. METHODS Literature search was conducted using four databases, including gray literature, with additional manual search of the references of selected articles. Eligibility criteria consisted of randomized clinical trials, without restriction regarding the date or language of the publication. Two independent reviewers performed the article selection and data extraction. The random-effects meta-analysis used a non-standard technique to assess the mean difference in days to achieve full enteral nutrition, carried out by the Stata 15 statistic program. RESULTS The systematic review comprised 10 studies, and five were selected for meta-analysis, with a population of 764 VLBW-PTNB and gestational age of birth between 25 and 32 weeks. The studies were conducted between 2011 and 2018 in North America, Asia and Africa, with only one conducted in South America. Altogether, they reported the number of days it took 708 VLBW-PTNB to achieve full enteral nutrition, with newborns treated with immunotherapy showing a shorter time in only three studies. Meta-analysis showed a mean difference of -4.26 days, (95% CI -7.44; -1.08d), with high heterogeneity (I2 = 83.1%). CONCLUSION The use of oropharyngeal colostrum immunotherapy can reduce the time for VLBW-PTNB to achieve full nutrition when compared to those who used a placebo or received routine care.
Full text:
Available
Collection:
International databases
Database:
BBO - Dentistry
/
LILACS
Main subject:
Colostrum
/
Enterocolitis, Necrotizing
Type of study:
Controlled clinical trial
/
Practice guideline
/
Systematic review
Limits:
Child, preschool
/
Female
/
Humans
/
Infant
/
Pregnancy
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. saúde pública (Online)
Journal subject:
Sa£de P£blica
Year:
2021
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Secretaria de Estado de Saúde do Distrito Federal/BR
/
Universidade Estadual de Feira de Santana/BR
/
Universidade de Brasília/BR