Large diameter Advanta V12 covered stent trial for coarctation of the aorta: COARC Study
Circ., cariovasc. interv. (Print)
; 14(12): 010576, Dec. 2021.
Article
in English
| CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1354074
Responsible library:
BR79.1
ABSTRACT
BACKGROUND:
Covered stent implantation for treatment of coarctation of the aorta (CoA) is effective and can prevent aortic wall injury. Prospective studies with long-term follow-up, including imaging, are lacking. We report the acute and long-term outcomes for use of the Large Diameter Advanta V12 covered stent for treatment of native and recurrent CoA.METHODS:
A prospective, multicenter, nonrandomized study was performed including 70 patients (43 male), median age 17 years, median weight 57.4 kg with CoA who underwent implantation of the Large Diameter Advanta V12 covered stent. Annual follow-up for 5 years included Doppler echocardiography to calculate diastolic velocity systolic velocity ratio.RESULTS:
CoA diameter increased from 5.6±3.6 to 14.9±3.9 mm (P<0.0001) and the pressure gradient decreased from 35.8±16.2 to 5.6±7.9 mm Hg (P<0.0001). Preimplantation diastolic velocity systolic velocity of 0.6±0.16 dropped to 0.34±0.13 (P<0.0001) and was maintained at 5 years. Computed tomography angiograms at 12 months post implantation demonstrated the stent transverse arch diameter to be similar, 0.91±0.09 to post procedure 0.86±0.14. Major adverse vascular events at 30 days and 12 months were 1.4% and 4.3%, respectively. Significant adverse events included three patients who required stent implantation to treat infolding. There were no mortalities.CONCLUSIONS:
The Large Diameter Advanta V12 covered stent is safe and effective for the treatment of CoA with an immediate and sustained reduction of the pressure gradient over 12 months and 5 years as assessed by preimplantation and post implantation Doppler echocardiography and 12-month computed tomography angiography.
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Collection:
National databases
/
Brazil
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
/
Congenital and Chromosomal Anomalies
/
Other circulatory Diseases
Database:
CONASS
/
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Main subject:
Aortic Coarctation
/
Computed Tomography Angiography
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Journal:
Circ., cariovasc. interv. (Print)
Year:
2021
Document type:
Article
Institution/Affiliation country:
Bristol Royal Hospital for Children/GB
/
Cardiovascular Center Frankfurt/DE
/
Children's Hospital of Westmead/AU
/
Deutsches Herzzentrum Berlin and Herz- und Diabeteszentrum Bad Oeynhausen/DE
/
Deutsches Kinderherzzentrum Sankt Augustin/DE
/
Instituto Dante Pazzanese de Cardiologia/BR
/
Policlinico San Donato Hospital/IT
/
Schneider Children's Medical Center of Israel/IL
/
The Hospital for Sick Children/CA