Heterogeneous trajectories in schizophrenia: insights from neurodevelopment and neuroprogression models
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 44(1): 74-80, Jan.-Feb. 2022. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1360176
Responsible library:
BR1.1
ABSTRACT
The notion that schizophrenia is a neuroprogressive disorder is based on clinical perception of cumulative impairments over time and is supported by neuroimaging and biomarker research. Nevertheless, increasing evidence has indicated that schizophrenia first emerges as a neurodevelopmental disorder that could follow various pathways, some of them neuroprogressive. The objective of this review is to revisit basic research on cognitive processes and neuroimaging findings in a search for candidate keys to the intricate connections between neurodevelopment and neuroprogression in schizophrenia. In the complete panorama, schizophrenia is a neurodevelopmental disorder, possibly associated with an additional burden over the course of the disease through pathologically accelerated aging, and cognitive heterogeneity may explain the different trajectories of each patient.
Full text:
Available
Collection:
International databases
Database:
LILACS
Type of study:
Prognostic study
Language:
English
Journal:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Journal subject:
Psychiatry
Year:
2022
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Hospital de Clínicas de Porto Alegre (HCPA)/BR