Overweight/obesity in adolescents with phenylketonuria: protective and predisposing factors
J. pediatr. (Rio J.)
; 98(1): 104-110, Jan.-Feb. 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1360562
Responsible library:
BR1.1
ABSTRACT
Abstract Objective:
To estimate the prevalence and factors associated with overweight/obesity development in adolescents with early diagnosed phenylketonuria treated exclusively by diet.Methodology:
In this cross-sectional study anthropometric measurements, serum phenylalanine levels, and 10 metabolites associated with lipid and carbohydrate metabolism were analyzed in 101 adolescents aged 10-20 years. Adolescents were categorized into overweight/obesity and eutrophic/low body mass index groups. These patients were compared using Student's t-test, Pearson's chi-square test, Wald's chi-square test for multivariate analysis. Further, to verify whether the prevalence of overweight/obesity found in the study population was similar to that in the general population, the authors compared the nutritional status of 46 patients aged 13-17 years with that of healthy students of the same age from the National School Health Survey using the chi-square test for adherence. The significance threshold was p < 0.5.Results:
The prevalence of overweight/obesity in adolescents was 27.7%. There was no difference in prevalence between sexes. Older age was a protective factor and Increased Homeostasis Model Assessment Insulin Resistance index and high phenylalanine and low-density lipoprotein cholesterol levels were predictive factors for overweight/obesity. The equality hypothesis was not rejected in the comparison of nutritional states of 46 patients aged 13-17 years and healthy students of the same age.Conclusion:
The prevalence of overweight/obesity in phenylketonuria adolescents was similar to what is found in healthy adolescents.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Phenylketonurias
/
Pediatric Obesity
Type of study:
Diagnostic study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Humans
Language:
English
Journal:
J. pediatr. (Rio J.)
Journal subject:
Pediatrics
Year:
2022
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Minas/BR
/
Pontifícia Universidade Católica de Minas Gerais (PUC-Minas)/BR
/
Universidade Federal de Minas Gerais (UFMG)/BR