Survival Analysis in Elderly Patients with Glioblastomas: The Influence of Clinical Status, Tumor and Surgical Features
Arq. bras. neurocir
; 37(4): 297-303, 15/12/2018.
Article
in English
| LILACS
| ID: biblio-1362638
Responsible library:
BR1.1
ABSTRACT
Introduction Glioblastomas are malignant neoplasms, notorious for their poor prognosis. We have conducted a survival analysis in a sample of elderly patients with glioblastomas. Methods The sample of the present study consisted of elderly patients consecutively admitted from January 2014 to January 2016 (24 months) at the Hospital do Servidor Público Estadual de São Paulo. We have evaluated the impact of age, Karnofsky scale (KS) score, tumor location, and occurrence of perioperative complications. Results A total of 42 patients were analyzed. Of these, 23 (54.7%) were men, and 19 (45.3%) were women. Patients > 60 years old, with low KS score, deep-seated tumors, and those with perioperative complications had worst outcomes. Discussion and conclusion Surgery, perioperative chemotherapy and radiotherapy add survival time and quality of life to these patients. In patients with low KS score, isolated radiotherapy and/or chemotherapy might be adequate. Decreasing perioperative complications is essential to adequately deliver adjuvant therapy in elderly patients.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Postoperative Complications
/
Prognosis
/
Glioblastoma
/
Kaplan-Meier Estimate
Type of study:
Prognostic study
Aspects:
Patient-preference
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arq. bras. neurocir
Journal subject:
Cirurgia
/
Neurosurgery
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Department of Neurosurgery, Hospital do Servidor Público Estadual de São Paulo/BR