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Evaluation of the persistent organic pollutants association with type 2 diabetes: A prospective study from Karachi, Pakistan / Avaliação da associação de poluentes orgânicos persistentes com diabetes tipo 2: um estudo prospectivo de Karachi, Paquistão
Khwaja, S; Zahid, M; Karim, A; Gurganari, L; Aziz, Z; Rasheed, A.
Affiliation
  • Khwaja, S; Federal Urdu University of Arts. Science, and Technology. Department of Zoology. Karachi. PK
  • Zahid, M; Federal Urdu University of Arts. Science, and Technology. Department of Zoology. Karachi. PK
  • Karim, A; Sardar Bahadur Khan Womens University. Department of Zoology. Quetta. PK
  • Gurganari, L; University of Balochistan. Department of Zoology. Quetta. PK
  • Aziz, Z; Federal Urdu University of Arts, Science and Technology. Department of Statistics. Karachi. PK
  • Rasheed, A; Federal Urdu University of Arts. Science, and Technology. Department of Zoology. Karachi. PK
Braz. j. biol ; 84: e256132, 2024. tab, graf
Article in En | VETINDEX | ID: biblio-1374651
Responsible library: BR68.1
Localization: BR68.1
ABSTRACT
The aim of this study is to determine the association between environmental organic pollutants with type 2 diabetes. This prospective study was conducted in Federal Urdu University of Arts, Science and Technology (FUUAST) Gulshan-e-Iqbal Campus Karachi in duration from January 2016 to June 2017. This study was ethically approved from the Institutional Review Board of FUUAST. The study included 50 male and female convenient subjects with type 2 diabetes. Subject with other type of diabetes was excluded. Consent was obtained by each individual. Self-structured questionnaire was used for data collection. The comparative results suggest that the maximum level of summation polychlorinated biphenyls (PCBs) mean value was found in age group 27-33 as 0.695 mg/kg in 73% having total individual eleven. Median (interquartile range) of pesticides levels among subjects with normal weight, over weight and obesity were 0.49 (0.26-2.13), 1.53 (0.60-2.65), and 1.60 (1.23-2.05) respectively. It was observed that Organochlorine pesticides (OCS) levels of subjects with overweight and obesity were almost similar (P-value > 0.05) but significantly higher as compared to subjects with normal weight (P-value < 0.05). No significant differences were observed between PCB levels of subjects in terms of body mass index (BMI). In present study we trace the important elements involve in the deposition of persistent organic pollutants and established an association between pollutants with etiology of diabetes and associated disorders such as obesity.
RESUMO
O objetivo deste estudo é determinar a associação entre poluentes orgânicos ambientais com diabetes tipo 2. Este estudo prospectivo foi conduzido na Universidade Federal Urdu de Artes, Ciência e Tecnologia (FUUAST), Gulshan-e-Iqbal, Campus Karachi, com duração de janeiro de 2016 a junho de 2017. Este estudo foi eticamente aprovado pelo Comitê de Revisão Institucional da FUUAST. O estudo incluiu 50 indivíduos convenientes do sexo masculino e feminino com diabetes tipo 2. Indivíduos com outro tipo de diabetes foram excluídos. O consentimento foi obtido por cada indivíduo. Um questionário autoestruturado foi utilizado para a coleta de dados. Os resultados comparativos sugerem que o nível máximo de soma de bifenilas policloradas (PCBs) valor médio foi encontrado na faixa etária 27-33 como 0,695 mg / kg em 73%, tendo total de 11 indivíduos. A mediana (intervalo interquartil) dos níveis de pesticidas entre indivíduos com peso normal, sobrepeso e obesidade foi de 0.49 (0.26-2.13), 1.53 (0.60-2.65) e 1.60 (1.23-2.05), respectivamente. Observou-se que os níveis de pesticidas organoclorados (OCS) de indivíduos com sobrepeso e obesidade eram quase semelhantes (valor P > 0.05), mas significativamente maiores em comparação com indivíduos com peso normal (valor P < 0.05). Não foram observadas diferenças significativas entre os níveis de PCB dos indivíduos em termos de índice de massa corporal (IMC). No presente estudo, rastreamos os elementos importantes envolvidos na deposição de poluentes orgânicos persistentes e estabelecemos uma associação entre os poluentes com a etiologia do diabetes e doenças associadas, como a obesidade.
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Full text: 1 Database: VETINDEX Main subject: Surveys and Questionnaires / Diabetes Mellitus, Type 2 / Persistent Organic Pollutants Limits: Humans Country/Region as subject: Asia Language: En Journal: Braz. j. biol Year: 2024 Document type: Article

Full text: 1 Database: VETINDEX Main subject: Surveys and Questionnaires / Diabetes Mellitus, Type 2 / Persistent Organic Pollutants Limits: Humans Country/Region as subject: Asia Language: En Journal: Braz. j. biol Year: 2024 Document type: Article