Therapeutics in radiation-induced proctopathy: a systematic review
J. coloproctol. (Rio J., Impr.)
; 42(1): 85-98, Jan.-Mar. 2022. tab, ilus
Article
in English
| LILACS
| ID: biblio-1375753
Responsible library:
BR545.3
ABSTRACT
Malignant neoplasms are increasingly prevalent in the daily clinical practice. Up to 61% of patients with pelvic malignancies undergo pelvic radiotherapy in different doses, which may cause intestinal damage, and the rectum is the segment most frequently affected due to its fixed position in the pelvis. Currently, there are several strategies to minimize the effects of radiation on the tissues surrounding the neoplastic site; despite those strategies, radiotherapy can still result in serious damage to organs and structures, and these injuries accompany patients throughout their lives. One of the most common damages resulting from pelvic radiotherapy is acute proctitis.The diagnosis is confirmed by visualizing the rectal mucosa through rigid or flexible rectosigmoidoscopy and colonoscopy. The objective of the present study was to review the forms of radiation-induced proctopathytherapy, and to evaluate the results of each method to propose a standardization for the treatment of this pathology. Despite the prevalence of radiation-induced proctopathy, there is no definitive standardized treatment strategy so far. The first approach can be tried with local agents, such as mesalazine and formalin. For refractory cases, control can usually be achieved with argon plasma coagulation, hyperbaric oxygen, and radiofrequency ablation therapies. Regarding the study of radiation-induced proctopathy, there is a lack of robust studies with large samples and standardized therapies to be compared. There is a lack of double-blinded, randomized controlled studies to determine a definitive standard treatment algorithm. (AU)
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Proctitis
/
Radiotherapy
/
Colitis
Type of study:
Controlled clinical trial
/
Risk factors
/
Systematic review
Language:
English
Journal:
J. coloproctol. (Rio J., Impr.)
Journal subject:
Cirurgia
/
Doenas Retais
/
Doenas do Colo
/
Gastroenterology
/
Cirurgia
Year:
2022
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Sociedade Brasileira de Coloproctologia/BR
/
Universidade Federal de Minas Gerais/BR