Cholestatic pruritus: a knowledge update
An. bras. dermatol
; An. bras. dermatol;97(3): 332-337, 2022. tab, graf
Article
in En
|
LILACS-Express
| LILACS
| ID: biblio-1383582
Responsible library:
BR1.1
ABSTRACT
Abstract This review is focused on updating knowledge about cholestatic pruritus. It summarizes clinical-epidemiological characteristics, pathophysiology, diagnostic approach, and evidence-based therapeutic recommendations regarding this form of pruritus. Pruritus is a frequent symptom that accompanies several liver diseases, particularly cholestatic ones. The symptom may be mild and tolerable, but it can also dramatically reduce the quality of life. Although the exact pathophysiology of this form of pruritus remains unclear, current evidence supports a mixed origin. It is extremely important for dermatologists to have knowledge about cholestatic pruritus since they are usually the first physicians to be sought by the patient when they experience the symptom. In the absence of specific dermatological alterations, cholestasis must always be considered as a possible cause of pruritus. In addition to allowing an adequate diagnosis, a better pathophysiological understanding of hepatic pruritus provides the identification of new therapeutic targets and, consequently, optimization of the approach in patients with this condition.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Type of study:
Guideline
/
Prognostic_studies
Aspects:
Patient_preference
Language:
En
Journal:
ABD: Anais brasileiros de dermatologia
/
An Bras Dermatol
/
An. bras. dermatol
/
An. bras. dermatol. (Online)
/
Anais brasileiros de dermatologia (Impresso)
Journal subject:
DERMATOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil