Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad? / Association between von Willebrand disease and angiodysplasia
Rev. méd. Chile
; 148(10): 1475-1480, oct. 2020. ilus, tab
Article
in Spanish
| LILACS
| ID: biblio-1389228
Responsible library:
CL126.2
ABSTRACT
Von Willebrand factor (vWf) is a fundamental multimeric plasma glycoprotein in the coagulation process. Its function is to mediate platelet adhesion and to stabilize circulating factor VIII. A functional or quantitative alteration of vWf gives rise to von Willebrand disease (vWD). The association between vWD and angiodysplasia was described in 1967, but it was only until 2011 that Starke et al demonstrated the in vitro and in vivo role of vWf in angiogenesis. Congenital or acquired vWf deficiency, especially of high molecular weight multimeters, not only favors bleeding, but also contributes to increased angiogenesis in these patients. The treatment should be focused both on the control of the acute episode of gastrointestinal bleeding, with vWf replacement therapy and local endoscopic treatment, as well as on the prevention of the progression of angiodysplasia and future bleeding. There are different published therapeutic approaches using vWf replacement that are not effective in all patients. Recently, angiogenesis inhibitor medications have been used.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Von Willebrand Diseases
/
Angiodysplasia
Type of study:
Etiology study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2020
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
/
Universidad Austral de Chile/CL