Hemorragia encefálica por angiopatía amiloidea / Amyloid angiopathy brain hemorrhage
Rev. méd. Chile
; 149(1): 76-87, ene. 2021. tab, ilus
Article
in Es
| LILACS
| ID: biblio-1389359
Responsible library:
CL1.1
ABSTRACT
Amyloid angiopathy (AA) is a selective deposition of amyloid in the walls of the brain vessels. It is a form of sporadic and localized amyloidosis, constituted by the Aβ4 protein, the same of Alzheimer's disease senile plaques. The most consistent clinical effect of AA is spontaneous brain hemorrhage (BH). It is the second most common cause of BH after arterial hypertension (HT). Other clinical manifestations are cognitive impairment and transient focal neurological episodes. AA BH is characteristically localized in the cerebral cortex and subcortical white matter (lobar hemorrhage), consistent with the preferential deposit of amyloid in the walls of leptomeningeal and intracortical small cerebral vessels. Other types of AA hemorrhagic complications are microbleeds (MB), cerebral convexity subarachnoid hemorrhage (cSAH) and superficial hemosiderosis (cSS). The diagnosis of AA BH is based on the Boston criteria. Using these criteria, several non-hemorrhagic biomarkers of AA have been identified that can be useful in its diagnosis. The principal AA BH risk factor is age, followed by cSS, MB, Apolipoprotein E gen ε2 and ε4 alleles, HT and the use of antithrombotics. This condition has a high recurrence rate that shares the same risk factors. There is no specific treatment for AA BH. It has a better prognosis than HT BH during the acute period, but worse on the long term, due to its high recurrence rate and cognitive impairment.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Subarachnoid Hemorrhage
/
Cerebral Amyloid Angiopathy
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2021
Document type:
Article
Affiliation country:
Chile
Country of publication:
Chile