Puesta al día: carcinoma paratiroideo / An update on parathyroid carcinoma
Rev. méd. Chile
; 149(3): 399-408, mar. 2021. tab, ilus
Article
in Spanish
| LILACS
| ID: biblio-1389472
Responsible library:
CL1.1
ABSTRACT
Parathyroid carcinoma is a rare malignant disease that presents as a sporadic or familial primary hyperparathyroidism (PHP). The latter is associated with some genetic syndromes. It occurs with equal frequency in both sexes, unlike PHP caused by parathyroid adenoma that is more common in women. It should be suspected in cases of severe hypercalcemia, with high parathyroid hormone levels and a palpable cervical mass. Given the difficulty in distinguishing between parathyroid carcinoma and adenoma prior to the surgery, the diagnosis is often made after parathyroidectomy. The only curative treatment is complete surgical resection with oncologic block resection of the primary tumor to ensure free margins. Adjuvant therapies with chemotherapy or radiation therapy do not modify overall or disease-free survival. Recurrences are common and re-operation of resectable recurrent disease is recommended. The palliative treatment of symptomatic hypercalcemia is crucial in persistent or recurrent disease after surgery since morbidity and mortality are more associated with hypercalcemia than with tumor burden.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Parathyroid Neoplasms
/
Hyperparathyroidism, Primary
/
Hypercalcemia
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2021
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Clínica Alemana/CL
/
Clínica Dávila/CL
/
Clínica Indisa/CL
/
Clínica Las Condes/CL
/
Hospital Clínico Universidad de Chile/CL
/
Hospital Dipreca/CL
/
Pontificia Universidad Católica de Chile/CL
/
Universidad Finis Terrae/CL
/
Universidad de Concepción/CL
/
Universidad de los Andes/CL