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Humoral response to spike S1 and S2 and nucleocapsidproteins on microarray after SARS­CoV­2 infection
Portilho, Amanda I; Silva, Valéria O; Ahagon, Cintia M; Matsuda, Elaine M; Oliveira, Elaine L. de; Silveira, Edilene P. R. da; Lima, Ana K. de Souza; Lindoso, José A. L; Campos, Ivana B. de; Hong, Marisa A; De Gaspari, Elizabeth; Brígido, Luís F. de Macedo.
Affiliation
  • Portilho, Amanda I; Instituto Adolfo Lutz. Centro de Imunologia. São Paulo. BR
  • Silva, Valéria O; Instituto Adolfo Lutz. Centro de Virologia. São Paulo. BR
  • Ahagon, Cintia M; Instituto Adolfo Lutz. Centro de Virologia. São Paulo. BR
  • Matsuda, Elaine M; Ambulatório de Doenças Infecciosas. Departamento de Saúde. Santo André. BR
  • Oliveira, Elaine L. de; Instituto Adolfo Lutz. Centro de Imunologia. São Paulo. BR
  • Silveira, Edilene P. R. da; Instituto Adolfo Lutz. Centro de Imunologia. São Paulo. BR
  • Lima, Ana K. de Souza; Instituto de Infectologia Emílio Ribas. São Paulo. BR
  • Lindoso, José A. L; Instituto de Infectologia Emílio Ribas. São Paulo. BR
  • Campos, Ivana B. de; Instituto Adolfo Lutz. Santo André. BR
  • Hong, Marisa A; Instituto Adolfo Lutz. Centro de Imunologia. São Paulo. BR
  • De Gaspari, Elizabeth; Instituto Adolfo Lutz. Centro de Imunologia. São Paulo. BR
  • Brígido, Luís F. de Macedo; Instituto Adolfo Lutz. Centro de Virologia. São Paulo. BR
J. med. virol ; 94(1): 178-185, 2022. tab, graf
Article in English | Coleciona SUS, Sec. Est. Saúde SP, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO | ID: biblio-1393242
Responsible library: BR91.2
Localization: BR76.1; Digital
ABSTRACT
Many aspects of the humoral immune response to severe acute respiratory syn-drome coronavirus 2 (SARS­CoV­2), such as its role in protection after natural in-fection, are still unclear. We evaluated IgA and IgG response to spike subunits 1 and2 (S1 and S2) and Nucleocapsid proteins of SARS­COV­2 in serum samples of 109volunteers with viral RNA detected or seroconversion with different clinical evolu-tion (asymptomatic, mild, moderate, and severe coronavirus disease 2019), using theViraChip®Test Kit. We observed that the quantification of antibodies to all antigenshad a positive correlation to disease severity, which was strongly associated with thepresence of comorbidities. Seroreversion was not uncommon even during the short(median of 77 days) observation, occurring in 15% of mild­asymptomatic cases at amedian of 55 days for IgG and 46 days for IgA. The time to reach the maximalantibody response did not differ significantly among recovered and deceased vo-lunteers. Our study illustrated the dynamic of anti­S1, anti­N, and anti­S2 IgA andIgG antibodies, and suggests that high production of IgG and IgA does not guaranteeprotection to disease severity and that functional responses that have been studiedby other groups, such as antibody avidity, need further attention. (AU)
Subject(s)


Full text: Available Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IALACERVO / SESSP-IALPROD / Coleciona SUS Main subject: Nucleocapsid / Protein Array Analysis / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Language: English Journal: J. med. virol Year: 2022 Document type: Article Institution/Affiliation country: Ambulatório de Doenças Infecciosas/BR / Instituto Adolfo Lutz/BR / Instituto de Infectologia Emílio Ribas/BR

Full text: Available Collection: National databases / Brazil Database: Sec. Est. Saúde SP / SESSP-IALACERVO / SESSP-IALPROD / Coleciona SUS Main subject: Nucleocapsid / Protein Array Analysis / Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 Language: English Journal: J. med. virol Year: 2022 Document type: Article Institution/Affiliation country: Ambulatório de Doenças Infecciosas/BR / Instituto Adolfo Lutz/BR / Instituto de Infectologia Emílio Ribas/BR
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