Predictors of recurrence of peritoneal carcinomatosis among patients with colorectal cancer following cytoreductive surgery alone versus cytoreductive surgery plus HIPEC
J. coloproctol. (Rio J., Impr.)
; 42(2): 107-114, Apr.-June 2022. tab, graf
Article
in En
| LILACS
| ID: biblio-1394411
Responsible library:
BR545.3
ABSTRACT
Background:
Peritoneal carcinomatosis (PC) is a lethal regional progression in patients with colorectal cancer (CRC). Treatment with complete cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) achieves better local control than systemic palliative chemotherapy.Objectives:
To assess the efficacy on the prognosis of CRS and HIPEC compared with CRS only and to identify possible clinicopathological factors associated with the recurrence of PC.Methods:
The present retrospective study included all colorectal carcinoma cases with PC subjected to CRS with or without HIPC from January 2009 to June 2018 at the National Cancer Institute (NCI), Cairo University, Cairo, Egypt. The outcome is evaluated in terms of recurrence-free survival (RFS) and its predictors.Results:
Out of the 61 patients, 45 patients (73.8%) underwent CRS plus HIPEC, and 16 (26.2%) underwent CRS alone. The 1-year RFS was 55.7%, with a median of 12 months. The risk factors for recurrence identified in the univariate analysis were T4 primary tumor, high-grade, positive lymphovascular invasion (LVI), positive extracapsular nodal spread, and patients treated with CRS only, without HIPEC. In the multivariate analysis, the independent risk factors for recurrence were high grade and patients treated with CRS only.Conclusion:
T4 primary tumor, high grade, positive LVI, and positive extracapsular nodal spread seemed to be important predictors of recurrence following the treatment of PC. Our study also demonstrated that the addition of HIPEC to CRS improved the RFS. (AU)Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Peritoneal Neoplasms
/
Colorectal Neoplasms
/
Cytoreduction Surgical Procedures
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
J. coloproctol. (Rio J., Impr.)
Journal subject:
Cirurgia
/
Doenas Retais
/
Doenas do Colo
/
GASTROENTEROLOGIA
/
Cirurgia
Year:
2022
Document type:
Article
Affiliation country:
Egypt
Country of publication:
Brazil