Blood DNA methylation marks discriminate Chagas cardiomyopathy disease clinical forms
Front. immunol
; 13(1020572): 1-6, Sept. 2022. graf
Article
in English
| CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1396604
Responsible library:
BR79.1
ABSTRACT
Chagas disease is a parasitic disease from South America, affecting around 7 million people worldwide. Decades after the infection, 30% of people develop chronic forms, including Chronic Chagas Cardiomyopathy (CCC), for which no treatment exists. Two stages characterized this form the moderate form, characterized by a heart ejection fraction (EF) ≥ 0.4, and the severe form, associated to an EF < 0.4. We propose two sets of DNA methylation biomarkers which can predict in blood CCC occurrence, and CCC stage. This analysis, based on machine learning algorithms, makes predictions with more than 95% accuracy in a test cohort. Beyond their predictive capacity, these CpGs are located near genes involved in the immune response, the nervous system, ion transport or ATP synthesis, pathways known to be deregulated in CCCs. Among these genes, some are also differentially expressed in heart tissues. Interestingly, the CpGs of interest are tagged to genes mainly involved in nervous and ionic processes. Given the close link between methylation and gene expression, these lists of CpGs promise to be not only good biomarkers, but also good indicators of key elements in the development of this pathology.
Full text:
Available
Collection:
National databases
/
Brazil
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Chagas Disease
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Neglected Diseases
Database:
CONASS
/
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Main subject:
Chagas Cardiomyopathy
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Chagas Disease
/
Methylation
Type of study:
Prognostic study
Language:
English
Journal:
Front. immunol
Year:
2022
Document type:
Article
Institution/Affiliation country:
Aix Marseille Univ, TAGC Theories and Approaches of Genomic Complexity, Institut MarMaRa/FR
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Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo (USP)/BR
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Laboratory of Immunology, Heart Institute Instituto do Coração (InCor), School of Medicine, University of São Paulo/BR
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Laboratory of Immunology, Heart Institute Instituto do Coração (InCor), School of Medicine, University of São Paulo, Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo/BR
/
Laboratory of Immunology, Universidade Federal Do Triângulo Mineiro (UFTM)/BR
/
Laboratório de Investigação Molecular em Cardiologia, Instituto de Cardiologia Dante Pazzanese (IDPC)/BR
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Myocardiopathies and Aortic Diseases Unit, Heart Institute, Instituto do Coração (InCor), School of Medicine, University of São Paulo/BR
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Pacemaker Clinic, Heart Institute Instituto do Coração (InCor), School of Medicine, University of São Paulo/BR
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RNA Systems Biology Laboratory (RSBL), Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte/BR
/
School of Medicine of Ribeirão Preto (FMRP), University of São Paulo/BR