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Walnut ointment promotes full-thickness burning wound healing: role of linoleic acid
Zhao, Dan; Xiao, Jinli; Qiang, Lijuan; Deng, Xingwang; An, Jingjing; Zhang, Qing; Zhao, Fang; Ma, Jiaxiang; Fang, Chao; Guan, Guangyu; Wu, Yinsheng; Xie, Yan.
Affiliation
  • Zhao, Dan; Ningxia Medical University General Hospital. Tissue and Organ Bank. Ningxia. CN
  • Xiao, Jinli; Ningxia Medical University. School of Clinical Medicine. Ningxia. CN
  • Qiang, Lijuan; Peoples Hospital of Ningxia Hui Autonomous Region. Department of Burns and Plastic Surgery. Ningxia. CN
  • Deng, Xingwang; The First Peoples Hospital of Shizuishan. Department of Burns and Plastic Surgery. Ningxia. CN
  • An, Jingjing; Ningxia Center for Diseases Prevention and Control. Department of Physical and Chemical Examination. Ningxia. CN
  • Zhang, Qing; Ningxia Medical University General Hospital. Tissue and Organ Bank. Ningxia. CN
  • Zhao, Fang; Ningxia Medical University General Hospital. Tissue and Organ Bank. Ningxia. CN
  • Ma, Jiaxiang; Ningxia Medical University General Hospital. Tissue and Organ Bank. Ningxia. CN
  • Fang, Chao; Ningxia Medical University General Hospital. Department of Burns and Plastic Surgery. Ningxia. CN
  • Guan, Guangyu; Ningxia Center for Diseases Prevention and Control. Department of Physical and Chemical Examination. Ningxia. CN
  • Wu, Yinsheng; Ningxia Medical University General Hospital. Department of Burns and Plastic Surgery. Ningxia. CN
  • Xie, Yan; Ningxia Center for Diseases Prevention and Control. Tissue and Organ Bank. Ningxia. CN
Acta cir. bras ; 37(9): e370902, 2022. tab, graf, ilus
Article in English | LILACS, VETINDEX | ID: biblio-1402980
Responsible library: BR68.1
ABSTRACT

Purpose:

To investigate the active ingredients of walnut ointment (WO) and its mechanism in repairing wounds.

Methods:

The ingredients of WO were detected by gas chromatography­mass spectrometry. The effect of linoleic acid (LA) was tested by in vitro Alamar Blue (AB) reagent. Image J software, histological and immunohistochemical analysis were used to confirm the healing effect of LA in the porcine skin model. The animals were euthanized after the experiment by injection of pentobarbital sodium.

Results:

LA, 24% in WO, promotes keratinocytes and fibroblasts proliferation, which were 50.09% and 15.07% respectively higher than control (p < 0.05). The healing rate of the LA group (96.02% ± 2%, 98.58% ± 0.78%) was higher than the saline group (82.11% ± 3.37%, 88.72% ± 1.73%) at week 3 and week 4 (p < 0.05). The epidermal thickness of the LA was 0.16 ± 0.04 mm greater and the expression of the P63 and CK10 proteins was stronger in the LA group than the control (p < 0.05).

Conclusions:

LA, which is the main components in WO can promote full-thickness burning wounds (FBWs) by stimulating cell proliferation and differentiation.
Subject(s)


Full text: Available Database: LILACS / VETINDEX Main subject: Ointments / Wound Healing / Keratinocytes / Linoleic Acid / Nuts Language: English Journal: Acta cir. bras Year: 2022 Document type: Article Institution/Affiliation country: Ningxia Center for Diseases Prevention and Control/CN / Ningxia Medical University General Hospital/CN / Ningxia Medical University/CN / Peoples Hospital of Ningxia Hui Autonomous Region/CN / The First Peoples Hospital of Shizuishan/CN

Full text: Available Database: LILACS / VETINDEX Main subject: Ointments / Wound Healing / Keratinocytes / Linoleic Acid / Nuts Language: English Journal: Acta cir. bras Year: 2022 Document type: Article Institution/Affiliation country: Ningxia Center for Diseases Prevention and Control/CN / Ningxia Medical University General Hospital/CN / Ningxia Medical University/CN / Peoples Hospital of Ningxia Hui Autonomous Region/CN / The First Peoples Hospital of Shizuishan/CN
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