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Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice
Yeom, Mijung; Ahn, Sora; Jang, Sun-Young; Jang, Jae-Hwan; Lee, Youngrye; Hahm, Dae-Hyun; Park, Hi-Joon.
Affiliation
  • Yeom, Mijung; Kyung Hee University. College of Korean Medicine. Acupuncture and Meridian Science Research Center (AMSRC). Seoul. KR
  • Ahn, Sora; Kyung Hee University. College of Korean Medicine. Acupuncture and Meridian Science Research Center (AMSRC). Seoul. KR
  • Jang, Sun-Young; Kyung Hee University. College of Korean Medicine. Acupuncture and Meridian Science Research Center (AMSRC). Seoul. KR
  • Jang, Jae-Hwan; Kyung Hee University. College of Korean Medicine. Acupuncture and Meridian Science Research Center (AMSRC). Seoul. KR
  • Lee, Youngrye; Kyung Hee University. College of Korean Medicine. Department of Meridian Medical Science. Seoul. KR
  • Hahm, Dae-Hyun; Kyung Hee University. College of Korean Medicine. Acupuncture and Meridian Science Research Center (AMSRC). Seoul. KR
  • Park, Hi-Joon; Kyung Hee University. College of Korean Medicine. Acupuncture and Meridian Science Research Center (AMSRC). Seoul. KR
Biol. Res ; 55: 28-28, 2022. graf
Article in English | LILACS | ID: biblio-1403567
Responsible library: CL1.1
ABSTRACT
Atopic dermatitis (AD) is highly comorbid with negative emotions such as anxiety and depression. Although acupuncture has demonstrated efficacy in AD, its influence on comorbid anxiety and depression remains unclear. We sought to explore the impact and mechanisms of action of acupuncture on comorbid anxiety and depression of AD. AD-like skin lesions were induced by the topical application of MC903 to the mouse cheek. Acupuncture was performed at Gok-Ji (LI11) acupoints. AD-like phenotypes were quantified by lesion scores, scratching behavior, and histopathological changes. The effects of acupuncture on comorbid anxiety and depression-like behaviors were assessed using the elevated plus-maze (EPM), open-field tests (OFT), and tail-suspension test (TST). In addition, biochemical changes in the brain reward regions were investigated by immunoblotting for the expression of tyrosine hydroxylase (TH), dopamine D1 receptor (D1R), phospho-dopamine and cAMP-regulated phosphoprotein-32 kDa (pDARPP-32), phospho-cAMP response element binding protein (pCREB), ΔFosB, and brain-derived neurotrophic factor (BDNF) in the nucleus accumbens, dorsolateral striatum, and ventral tegmental area. Acupuncture effectively improved the chronic itching and robust AD-like skin lesions with epidermal thickening. Additionally, it considerably reduced comorbid anxiety- and depression-like symptoms, as indicated by more time spent in the open arms of the EPM and in the center of the open field and less time spent immobile in the TST. Higher pCREB, ΔFosB, BDNF, and pDARPP-32 levels, and reduced TH and D1R protein expression in the brain reward regions of AD mice were reversed by acupuncture treatment. The beneficial effects of acupuncture on clinical symptoms (scratching behavior) and comorbid psychological distress in AD strongly correlated with dorsal striatal ΔFosB levels. Collectively, these data indicate that acupuncture had a significant, positive impact on comorbid anxiety- and depression-like behaviors by modulating neuroadaptation in the brain reward circuit in mice with AD, providing a novel perspective for the non-pharmacological management of psychiatric comorbidities of AD.
Subject(s)


Full text: Available Collection: International databases Database: LILACS Main subject: Acupuncture Therapy / Dermatitis, Atopic Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2022 Document type: Article Affiliation country: South Korea Institution/Affiliation country: Kyung Hee University/KR

Full text: Available Collection: International databases Database: LILACS Main subject: Acupuncture Therapy / Dermatitis, Atopic Limits: Animals Language: English Journal: Biol. Res Journal subject: Biology Year: 2022 Document type: Article Affiliation country: South Korea Institution/Affiliation country: Kyung Hee University/KR
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