Evaluation of vitamin D and inflammatory markers in elderly
Braz. J. Pharm. Sci. (Online)
; 58: e20248, 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1403688
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Abstract Vitamin D is an immune modulator, in addition to being interrelated with calcium homeostasis and bone metabolism. Recent studies have associated vitamin D with inflammatory processes. C-reactive protein (CRP), platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) have been used to determine inflammation. There is no consensus on the use of these markers to determine an association between inflammation and vitamin D levels. The objective of this study was to evaluate the association between inflammatory markers and vitamin D in the elderly. A cross-sectional, descriptive study was performed based on the analysis of vitamin D, CRP (quantitative determination of C-Reactive Protein by the ultra-sensitive method) and blood count of institutionalized elderly. In this study, 64% showed vitamin D deficiency, with mean value of 22 ng/mL. In the vitamin D deficient group, the mean values found were CRP 4.5 mg/L; NLR 2.35 and PLR 119. In the group without vitamin D deficiency the mean values were CRP 4 mg/L; NLR 1.87 and PLR 111 without statistical difference between the values of the analyzed parameters. The results point to a predominant profile of vitamin D deficiency in the evaluated individuals. No association was found between vitamin D values and the inflammatory markers analyzed.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Vitamin D
/
Vitamin D Deficiency
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Aged
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Inflammation
/
Anti-Inflammatory Agents
Limits:
Aged
/
Aged, 80 and over
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Female
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Humans
/
Male
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Ponta Grossa/BR
/
São Vicente de Paulo Nursing Home/BR