Biological properties of Schinus terebinthifolia Raddi essential oil
Braz. J. Pharm. Sci. (Online)
; 58: e20417, 2022. tab, graf
Article
in English
| LILACS
| ID: biblio-1403712
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Abstract Schinus terebinthifolia Raddi green fruits essential oil (EO) was evaluated regarding its phytochemical profile, antimicrobial and cytotoxic activities, and toxicity. Gas chromatography with mass spectrometry was applied to identify its constituents, thereafter the minimum inhibitory concentration, minimum bactericidal and fungicidal concentrations, and its antibiofilm activity were evaluated. The EO cytotoxicity was assessed in tumor and non-tumor human cells, and in vivo toxicity was evaluated in a Galleria mellonella model. The major constituents of S. terebinthifolia EO were alpha-phellandrene and beta-phellandrene. The EO had a weak activity against all strains of Candida albicans (MIC 1000µg/mL) and had no activity against non-albicans strains, bacteria, and C. albicans biofilm. Cytostatic activity against all tumor cell lines was shown. Additionally, cell viability remained at EO concentrations up to 62.5 µg/mL. At 16 mg/mL, 50% hemolysis was observed, and it had low toxicity in vivo. Overall, the S. terebinthifolia EO was characterized by low antimicrobial and antibiofilm activities, with no evidence of toxicity to human tumor and non-tumor cells
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Oils, Volatile
/
Anacardiaceae
/
Fruit
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2022
Document type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Federal University of Paraíba/BR
/
State University of Paraíba/BR
/
University of Campinas/BR
/
University of Florida College of Dentistry/US