Lack of serological and molecular evidences of Zika virus circulation in non-human primates in three states from Brazil
Mem. Inst. Oswaldo Cruz
; 117: e220012, 2022. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1406001
Responsible library:
BR1.1
ABSTRACT
BACKGROUND Zika virus (ZIKV) was discovered in 1947 with the virus isolation from Rhesus monkey (Macaca mulatta) in Uganda forest, Africa. Old World Primates are involved in a sylvatic cycle of maintenance of this arbovirus, however a limited knowledge about the role of New World primates in ZIKV transmission cycles has been established. OBJECTIVE This work aimed to investigate the presence of enzootic circulation of ZIKV in New World Primates from three Brazilian states São Paulo, Paraíba, and Paraná. METHODS We analyzed 100 non-human primate samples collected in 2018 and 2020 from free-ranging and captive environments from São Paulo (six municipalities belonging to Sorocaba region), Paraíba (João Pessoa municipality), and Paraná (Foz do Iguaçu municipality) using reverse transcriptase quantitative polymerase reaction (RT-qPCR) assays, indirect enzyme-linked immunosorbent assay (ELISA), and plaque reduction neutralization test (PRNT). FINDINGS All samples (n = 141) tested negative for the presence of ZIKV genome from tissue and blood samples. In addition, all sera (n = 58) from Foz do Iguaçu' non-human primates (NHPs) were negative in serological assays. MAIN CONCLUSION No evidence of ZIKV circulation (molecular and serological) was found in neotropical primates. In addition, the absence of antibodies against ZIKV suggests the absence of previous viral exposure of NHPs from Foz do Iguaçu-PR.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
LILACS
Country/Region as subject:
South America
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Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
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Parasitology
Year:
2022
Document type:
Article
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Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Escola de Medicina de São José do Rio Preto/BR
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Refúgio Biológico Bela Vista/BR
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Universidade Estadual Paulista Júlio de Mesquita Filho/BR
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Universidade Federal da Integração Latino-Americana/BR
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Universidade Federal da Paraíba/BR
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Universidade Federal de Campina Grande/BR
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Universidade Federal do Paraná/BR
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Zoológico Bosque do Guarani/BR
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Zoológico Municipal Quinzinho de Barros/BR