A prospective study of living kidney donors: 6 years follow-up from a cardiovascular disease risk perspective
Rev. Assoc. Med. Bras. (1992, Impr.)
; 68(8): 1042-1047, Aug. 2022. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1406601
Responsible library:
BR1.1
ABSTRACT
SUMMARY OBJECTIVE:
The purpose of this prospective study was to evaluate the clinical, laboratory, and donation-specific outcomes of living kidney donors 6 years after donation.METHODS:
We included a total of 93 kidney donors and 54 age- and sex-matched individuals as control group through a type 2 cohort consecutive recruitment. We detected kidney function abnormalities and the presence of hypertension, diabetes, and cardiovascular events during the 6 years follow-up period.RESULTS:
The mean serum creatinine levels were higher (p<0.001), and the estimated glomerular filtration rate levels were lower (p<0.001) in living kidney donors 6 years after donation when compared with controls. The protein/creatinine ratio of the study population was also higher (p=0.014). There was no difference in outcomes between the groups for end-stage kidney disease and cardiovascular mortality. A higher rate of new-onset hypertension (6.4 vs. 32.9%), diabetes mellitus (0.0 vs. 4.3%), chronic kidney disease (0.0 vs. 2.1%), and cardiovascular disease (0.0 vs. 2.1%) was demonstrated among donors 6 years after donation (p<0.001, respectively).CONCLUSION:
Our data have demonstrated that the reduction in Glomerular filtration rate induced by kidney donation might cause an increase in adverse renal and cardiovascular events.
Full text:
Available
Collection:
International databases
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Kidney, Renal Pelvis and Ureter Cancer
Database:
LILACS
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2022
Document type:
Article
Affiliation country:
Turkey
Institution/Affiliation country:
Kartal Dr. Lutfi Kırdar City Hospital/TR
/
University of Health Sciences/TR