Efectividad de anticoagulación regional con citrato en terapia de reemplazo renal continua / Effectiveness of regional citrate anticoagulation in continuous renal replacement therapy
Rev. méd. Chile
; 150(3): 283-288, mar. 2022. ilus, tab, graf
Article
in Spanish
| LILACS
| ID: biblio-1409812
Responsible library:
CL126.2
ABSTRACT
BACKGROUND:
Anticoagulation in continuous renal replacement therapy (CRRT) is essential to counteract the coagulation cascade activation, induced by the dialysis circuit. Heparin is the most widely used anticoagulant, followed by regional citrate anticoagulation (RCA).AIM:
To determine the effectiveness and safety of anticoagulant treatment with citrate in CRRT. Material andMethods:
Retrospective study of adults in CRRT hospitalized between the years 2014 and 2020 in critical units, who required change to RCA according to established protocols.RESULTS:
We studied 24 patients aged 63 ± 13 years (12 females). The reasons for admission were acute kidney injury (AKI) in 80% and stage 5 chronic kidney disease in 20%. The indication of RCA in 75% of patients was by coagulation of more than 3 circuits in 24 hours. The duration of the circuit in RCA was 18.5 ± 4.8 hours versus 11.9 ± 4.9 hours with heparin (p < 0.0001). There were 19 mild complications that did not affect the RCA.Conclusions:
RCA is feasible to perform, it is a safe and efficient procedure if it is protocolized, allowing a longer duration of the dialysis circuit.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Acute Kidney Injury
/
Continuous Renal Replacement Therapy
Type of study:
Practice guideline
/
Observational study
Limits:
Adult
/
Female
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2022
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Clínico Universidad de Chile/CL
/
Hospital El Pino/CL