A Potential SARS-CoV-2 Variant of Interest (VOI) Harboring Mutation E484K in the Spike Protein Was Identified within Lineage B 1 1 33 Circulating in Brazil
Viruses
; 13(5): 1-20, 2021.
Article
in English
| LILACS, CONASS, Coleciona SUS, Sec. Est. Saúde SP, SESSP-IALPROD, Sec. Est. Saúde SP
| ID: biblio-1416914
Responsible library:
BR91.2
Localization: BR91.2; P
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Brazil was dominated by two lineages designated as B.1.1.28 and B.1.1.33. The two SARS-CoV-2 variants harboring mutations at the receptor-binding domain of the Spike (S) protein, designated as lineages P.1 and P.2, evolved from lineage B.1.1.28 and are rapidly spreading in Brazil. Lineage P.1 is considered a Variant of Concern (VOC) because of the presence of multiple mutations in the S protein (including K417T, E484K, N501Y), while lineage P.2 only harbors mutation SE484K and is considered a Variant of Interest (VOI). On the other hand, epidemiologically relevant B.1.1.33 deriving lineages have not been described so far. Here we report the identification of a new SARS-CoV-2 VOI within lineage B.1.1.33 that also harbors mutation SE484K and was detected in Brazil between November 2020 and February 2021. This VOI displayed four non-synonymous lineage-defining mutations (NSP3A1711V, NSP6F36L, SE484K, and NS7bE33A) and was designated as lineage N.9. The VOI N.9 probably emerged in August 2020 and has spread across different Brazilian states from the Southeast, South, North, and Northeast regions.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
CONASS
/
LILACS
/
Sec. Est. Saúde SP
/
SESSP-IALPROD
/
Coleciona SUS
Main subject:
Proteins
/
SARS-CoV-2
/
Mutation
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Viruses
Year:
2021
Document type:
Article
Institution/Affiliation country:
Fiocruz COVID-19 Genomic Surveillance Network, Fiocruz/BR
/
Fundação de Vigilância em Saúde do Amazonas/BR
/
Instituto Adolfo Lutz (IAL)/BR
/
Laboratório Central de Saúde Pública do Amazonas/BR
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Laboratório Central de Saúde Pública do Estado da Paraíba (LACEN-PB)/BR
/
Laboratório Central de Saúde Pública do Estado de Minas Gerais (LACEN-MG)/BR
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Laboratório Central de Saúde Pública do Estado de Santa Catarina (LACEN-SC)/BR
/
Laboratório Central de Saúde Pública do Estado do Alagoas (LACEN-AL)/BR
/
Laboratório Central de Saúde Pública do Estado do Espírito Santo (LACEN-ES)/BR
/
Laboratório Central de Saúde Pública do Estado do Maranhão (LACEN-MA)/BR