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Clinical outcome of Brazilian patients with non-small cell lung cancer in early stage harboring rare mutations in epidermal growth factor receptor
Machado-Rugolo, J.; Baldavira, C.M.; Prieto, T.G.; Olivieri, E.H.R.; Fabro, A.T.; Rainho, C.A.; Castelli, E.C.; Ribolla, P.E.M.; AbSaber, A.M.; Takagaki, T.; Nagai, M.A.; Capelozzi, V.L..
Affiliation
  • Machado-Rugolo, J.; Universidade de São Paulo. Departamento de Patologia, Faculdade de Medicina. Laboratório de Histomorfometria e Genômica Pulmonar. São Paulo. BR
  • Baldavira, C.M.; Universidade de São Paulo. Departamento de Patologia, Faculdade de Medicina. Laboratório de Histomorfometria e Genômica Pulmonar. São Paulo. BR
  • Prieto, T.G.; Universidade de São Paulo. Departamento de Patologia, Faculdade de Medicina. Laboratório de Histomorfometria e Genômica Pulmonar. São Paulo. BR
  • Olivieri, E.H.R.; AC Camargo Cancer Center. Centro Internacional de Pesquisa/CIPE. São Paulo. BR
  • Fabro, A.T.; Universidade de São Paulo. Departamento de Patologia, Faculdade de Medicina. Laboratório de Histomorfometria e Genômica Pulmonar. São Paulo. BR
  • Rainho, C.A.; Universidade Estadual Paulista. Departamento de Ciências Químicas e Biológicas. Instituto de Biociências. Botucatu. BR
  • Castelli, E.C.; Universidade Estadual Paulista. Unidade de Pesquisa Experimental, Faculdade de Medicina. Laboratório de Genética Molecular e Bioinformática. Botucatu. BR
  • Ribolla, P.E.M.; Universidade Estadual Paulista. Instituto de Biotecnologia. Botucatu. BR
  • AbSaber, A.M.; Universidade de São Paulo. Departamento de Patologia, Faculdade de Medicina. Laboratório de Histomorfometria e Genômica Pulmonar. São Paulo. BR
  • Takagaki, T.; Universidade de São Paulo. Instituto do Coração, Faculdade de Medicina. Divisão de Pneumologia. São Paulo. BR
  • Nagai, M.A.; Universidade de São Paulo. Faculdade de Medicina. Departamento de Radiologia e Oncologia. São Paulo. BR
  • Capelozzi, V.L.; Universidade de São Paulo. Departamento de Patologia, Faculdade de Medicina. Laboratório de Histomorfometria e Genômica Pulmonar. São Paulo. BR
Braz. j. med. biol. res ; 55: e12409, 2022. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1420743
Responsible library: BR1.1
ABSTRACT
The common epidermal growth factor receptor (EGFR) mutations, such as the L858R point mutation in exon 21 and the in-frame deletional mutation in exon 19, have been definitively associated with response to EGFR-tyrosine kinase inhibitors (EGFR-TKI). However, the clinical outcome and response to treatment for many other rarer mutations are still unclear. In this study, we report the results of Brazilian patients in stage IB-IIIA non-small cell lung cancer (NSCLC) following complete resection with minimal residual disease and EGFR mutations treated with adjuvant chemotherapy and/or EGFR-TKIs. The frequency of EGFR mutations was investigated in 70 cases of early stage NSCLC. Mutations in exons 18 and 20, uncommon mutations in exons 19 and 21, as well as in exons 3, 7, 14, 16, 22, 27, and 28, and/or the presence of different mutations in a single tumor (complex mutations) are considered rare. EGFR mutations were detected in 23 tumors (32.9%). Fourteen cases carried rare mutations and were treated with platinum-based chemotherapy and two cases were treated with erlotinib. The clinical outcome is described case by case with references to the literature. Notably, we found two rare EGFR mutations and one of them with an unknown response to chemotherapy and/or EGFR-TKIs. We have provided complementary information concerning the clinical outcome and treatment of patients with early stage NSCLC for several rare EGFR mutations not previously or only rarely reported. Description of cases harboring rare mutations can support the decision-making process in this subset of patients.


Full text: Available Collection: International databases Database: LILACS Type of study: Prognostic study Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2022 Document type: Article Affiliation country: Brazil Institution/Affiliation country: AC Camargo Cancer Center/BR / Universidade Estadual Paulista/BR / Universidade de São Paulo/BR

Full text: Available Collection: International databases Database: LILACS Type of study: Prognostic study Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2022 Document type: Article Affiliation country: Brazil Institution/Affiliation country: AC Camargo Cancer Center/BR / Universidade Estadual Paulista/BR / Universidade de São Paulo/BR
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