Association of Tumor Necrosis Factor-α (-G308A) Polymorphism with risk of Upper Gastrointestinal Bleeding from Schistosomiasis in Pernambuco
Rev. Soc. Bras. Med. Trop
; 56: e0654, 2023. tab
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1422880
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Background:
We evaluated the association between polymorphisms in the tumor necrosis factor alpha (TNF-α) (-G308A) gene and upper gastrointestinal bleeding (UGIB) in schistosomiasis.Methods:
This was a transverse study involving 294 Brazilian patients infected with Schistosoma mansoni.Results:
The homozygous A/A genotype in TNF-α (-G308A) showed a risk association (prevalence ratio = 1.90, p = 0.008) with UGIB. There was no statistically significant difference in serum TNF-α levels between the clinical groups.Conclusions:
The polymorphic TNF-α (-G308A) can be a risk factor for UGIB, in addition to being a potentially predictive factor for the severity of UGIB in schistosomiasis.
Full text:
Available
Collection:
International databases
Health context:
Neglected Diseases
Health problem:
Neglected Diseases
/
Schistosomiasis
/
Zoonoses
Database:
LILACS
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Rev. Soc. Bras. Med. Trop
Journal subject:
Tropical Medicine
Year:
2023
Document type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR