A review of the current diphtheria outbreaks
Afr. J. Clin. Exp. Microbiol
; 24(2): 1-10, 2023. figures, tables
Article
in English
| AIM (Africa)
| ID: biblio-1427772
Responsible library:
CG1.1
ABSTRACT
Corynebacterium diphtheriae is responsible for both endemic and epidemic diphtheria. The predisposing factor for this disease is the failure to immunize during childhood. Humans are the only hosts of the organism and is present in the upper respiratory tract. The organism is transmitted via airborne route and can cause respiratory obstruction and heart failure because of the exotoxin it produces. There is presently a resurgence of diphtheria outbreaks in Nigeria. The Nigeria Center for Disease Control (NCDC) was notified of suspected diphtheria outbreaks in Lagos and Kano States, Nigeria, in December 2022 and has been issuing monthly reports since that time. This review of the diphtheria outbreaks following online database searches on PubMed and Google Scholar as well as the NCDC/WHO websites and grey literatures, describes the current trend of the outbreaks globally, elucidated the different strains of Corynebacterium responsible for the outbreaks, identified the recent vaccine formulation developed to tackle the outbreaks, and provide information on vaccine delivery and efficacy studies in the country and globally.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 10: Communicable diseases
/
Target 3.3: End transmission of communicable diseases
Database:
AIM (Africa)
Main subject:
Actinomycetales
/
Diphtheria-Tetanus-Pertussis Vaccine
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Afr. J. Clin. Exp. Microbiol
Year:
2023
Document type:
Article
Institution/Affiliation country:
1928 Woodlawn Drive, Woodlawn, Maryland 21207/NG
/
Department of Medical Microbiology and Immunology, Nile University of Nigeria/NG
/
Department of Medical Microbiology and Parasitology, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University/NG
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Department of Medical Microbiology and Parasitology, Faculty of Health Sciences, Obafemi Awolowo University/NG
/
Nigeria Center for Disease Control (NCDC), Jabi, Abuja/NG