Genomic Surveillance of Yellow Fever Virus Epizootic in São Paulo, Brazil, 2016 2018
PLoS Pathog
; 16(8)2020.
Article
in English
| Sec. Est. Saúde SP, SESSP-CTDPROD, Sec. Est. Saúde SP
| ID: biblio-1428660
Responsible library:
BR91.2
Localization: BR91.2; P
ABSTRACT
São Paulo, a densely inhabited state in southeast Brazil that contains the fourth most populated city in the world, recently experienced its largest yellow fever virus (YFV) outbreak in decades. YFV does not normally circulate extensively in São Paulo, so most people were unvaccinated when the outbreak began. Surveillance in non-human primates (NHPs) is important for determining the magnitude and geographic extent of an epizootic, thereby helping to evaluate the risk of YFV spillover to humans. Data from infected NHPs can give more accurate insights into YFV spread than when using data from human cases alone. To contextualise human cases, identify epizootic foci and uncover the rate and direction of YFV spread in São Paulo, we generated and analysed virus genomic data and epizootic case data from NHPs in São Paulo. We report the occurrence of three spatiotemporally distinct phases of the outbreak in São Paulo prior to February 2018. We generated 51 new virus genomes from YFV positive cases identified in 23 different municipalities in São Paulo, mostly sampled from NHPs between October 2016 and January 2018. Although we observe substantial heterogeneity in lineage dispersal velocities between phylogenetic branches, continuous phylogeographic analyses of generated YFV genomes suggest that YFV
Full text:
Available
Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-CTDPROD
Main subject:
Genome
/
Richter Scale
/
Research Report
Type of study:
Screening study
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
PLoS Pathog
Year:
2020
Document type:
Article
Institution/Affiliation country:
Affiliation Department of Zoology/BR
/
Conceptualization, Data curation, Formal analysis/BR
/
Conceptualization, Funding acquisition/BR
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Department of Zoology, University of Oxford, Oxford/BR
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Instituto Adolfo Lutz/BR
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Instituto de Medicina Tropical/BR
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Instituto de Medicina Tropical, Departamento de Moléstias Infecciosas e Parasitárias/BR
/
Laboratório de Virologia Molecular/BR