Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus
Braz. J. Pharm. Sci. (Online)
; 59: e20052, 2023. graf
Article
in English
| LILACS
| ID: biblio-1429959
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Abstract The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations with SLE activity. The aim of this study is to investigate cell phenotypes associated to SLE diagnosis, treatment and activity. Twenty-eight SLE female patients (17 inactive, 11 active) and 10 healthy women were included in this study. Markers of natural killer (Nk), T and B cells in peripheral blood were evaluated by flow cytometry. Nkt cells were decreased only in SLE active patients. Activated CD4+, regulatory T FoxP3+ and B cells were decreased in both active and inactive SLE patients, compared to control group. The data corroborate the disruption of immune regulatory response in SLE patients and suggest phenotipic changes as possible biomarkers of SLE activity.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Flow Cytometry
/
Lupus Erythematosus, Systemic
Limits:
Female
/
Humans
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2023
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Minas Gerais/BR
/
Oswaldo Cruz Foundation/BR
/
Santa Casa/BR