Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy
Mem. Inst. Oswaldo Cruz
; 118: e220197, 2023. tab, graf
Article
in English
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LILACS-Express
| LILACS
| ID: biblio-1430844
Responsible library:
BR1.1
ABSTRACT
Diabetes is a chronic metabolic disease caused by a reduction in the production and/or action of insulin, with consequent development of hyperglycemia. Diabetic patients, especially those who develop neuropathy, presented dysbiosis, with an increase in the proportion of pathogenic bacteria and a decrease in the butyrate-producing bacteria. Due to this dysbiosis, diabetic patients presented a weakness of the intestinal permeability barrier and high bacterial product translocation to the bloodstream, in parallel to a high circulating levels of pro-inflammatory cytokines such as TNF-α. In this context, we propose here that dysbiosis-induced increased systemic levels of bacterial products, like lipopolysaccharide (LPS), leads to an increase in the production of pro-inflammatory cytokines, including TNF-α, by Schwann cells and spinal cord of diabetics, being crucial for the development of neuropathy.
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Database:
LILACS
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2023
Document type:
Article
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Cedars-Sinai Medical Center/US
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Fundação Oswaldo Cruz-Fiocruz/BR