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Smoking intensity increases diaphragm muscle injury: a clinicopathologic study
Nucci, Ricardo Aparecido Baptista; Busse, Alexandre Leopold; Souza, Romeu Rodrigues de; Maifrino, Laura Beatriz Mesiano; Pasqualucci, Carlos Augusto; Anaruma, Carlos Alberto; Leite, Renata Elaine Paraizo; Rodriguez, Roberta Diehl; Suemoto, Claudia Kimie; Jacob-Filho, Wilson.
Affiliation
  • Nucci, Ricardo Aparecido Baptista; Department of Pathology, Faculty of Medicine, University of São Paulo. Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo. São Paulo. BR
  • Busse, Alexandre Leopold; Department of Pathology, Faculty of Medicine, University of São Paulo. Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo. São Paulo. BR
  • Souza, Romeu Rodrigues de; Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo. Department of Anatomy, 9 de Julho University-UNINOVE. São Paulo. BR
  • Maifrino, Laura Beatriz Mesiano; Dante Pazzanese Institute of Cardiology. Laboratory of Clinical Analysis, Faculty of Medicine of the ABC District. São Paulo. BR
  • Pasqualucci, Carlos Augusto; Department of Pathology, Faculty of Medicine, University of São Paulo. São Paulo. BR
  • Anaruma, Carlos Alberto; Laboratory of Morphology and Physical Activity, Department of Physical Education, São Paulo State University "Júlio de Mesquita Filho". Rio Claro. BR
  • Leite, Renata Elaine Paraizo; Laboratory of Physiopathology in Aging (LIM-22), Department of Pathology, Faculty of Medicine, University of São Paulo. São Paulo. BR
  • Rodriguez, Roberta Diehl; Department of Pathology, Faculty of Medicine, University of São Paulo. São Paulo. BR
  • Suemoto, Claudia Kimie; Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo. São Paulo. BR
  • Jacob-Filho, Wilson; Department of Pathology, Faculty of Medicine, University of São Paulo. Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo. São Paulo. BR
J. clin. med ; 12(11): e3823, June 2023. ilus, tab
Article in English | CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1437642
Responsible library: BR79.1
ABSTRACT

BACKGROUND:

Studying the effects of smoking intensity is important to evaluate the risk of tobacco use on a range of illnesses, such as sarcopenia among the elderly. Thus, this study aimed to analyze the effects of pack-years of cigarette smoking on the diaphragm muscle (DIAm) histopathology of postmortem samples.

METHODS:

Subjects were divided into three groups never-smoker (n = 46); less than 30 pack-years of smoking (n = 12); and more than 30 pack-years of smoking (n = 30). Diaphragm samples were stained with Picrosirius red and hematoxylin and eosin stain for general structure.

RESULTS:

Participants with more than 30 pack-years of cigarette smoking had a significant increase in adipocytes, blood vessels and collagen deposit, as well as an increase in histopathological alterations.

CONCLUSIONS:

Pack-years of smoking was associated with DIAm injury. However, further clinicopathological studies are needed to confirm our findings.
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Full text: Available Collection: National databases / Brazil Database: CONASS / Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Diaphragm / Tobacco Products Language: English Journal: J. clin. med Year: 2023 Document type: Article Institution/Affiliation country: Dante Pazzanese Institute of Cardiology/BR / Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo/BR / Department of Pathology, Faculty of Medicine, University of São Paulo/BR / Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo/BR / Laboratory of Morphology and Physical Activity, Department of Physical Education, São Paulo State University "Júlio de Mesquita Filho"/BR / Laboratory of Physiopathology in Aging (LIM-22), Department of Pathology, Faculty of Medicine, University of São Paulo/BR
Fulltext
Add to My VHL
Print
XML
Search on Google

Full text: Available Collection: National databases / Brazil Database: CONASS / Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Diaphragm / Tobacco Products Language: English Journal: J. clin. med Year: 2023 Document type: Article Institution/Affiliation country: Dante Pazzanese Institute of Cardiology/BR / Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo/BR / Department of Pathology, Faculty of Medicine, University of São Paulo/BR / Laboratory of Medical Research in Aging (LIM-66), Division of Geriatrics, Faculty of Medicine, University of São Paulo/BR / Laboratory of Morphology and Physical Activity, Department of Physical Education, São Paulo State University "Júlio de Mesquita Filho"/BR / Laboratory of Physiopathology in Aging (LIM-22), Department of Pathology, Faculty of Medicine, University of São Paulo/BR