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Relación de IMC con marcadores de inflamación y hemoglobina glicosilada en niños y jóvenes con diabetes mellitus 1 / Relationship of BMI with markers of inflammation and glycosylated hemoglobin in children and young adults with diabetes mellitus 1
Duarte S, Lissette; Ávila A, Alejandra; Salas-Pérez, Francisca; Pérez B, Francisco.
Affiliation
  • Duarte S, Lissette; Universidad de Chile. Faculta de Medicina. Departamento de Nutrición. Santiago. CL
  • Ávila A, Alejandra; Universidad de Chile. Instituto de Investigaciones Materno Infantil (IDIMI). Santiago. CL
  • Salas-Pérez, Francisca; Universidad Bernardo O'Higgins. Rancagua. CL
  • Pérez B, Francisco; Universidad de Chile. Faculta de Medicina. Departamento de Nutrición. Santiago. CL
Rev. chil. endocrinol. diabetes ; 16(1): 10-16, 2023. ilus, tab
Article in Spanish | LILACS | ID: biblio-1438514
Responsible library: CL1.1
RESUMEN
La diabetes mellitus tipo 1 (DM1) es una enfermedad autoinmune que genera dependencia exógena de insulina de forma permanente, presenta inflamación subclínica crónica lo que conlleva a una elevación de marcadores de inflamación como factor de necrosis tumoral alfa (TNF-α), proteína C reactiva (PCR) e interleuquina 6 (IL-6).

OBJETIVO:

determinar la relación entre el IMC sobre los marcadores de inflamación y el control metabólico en niños y jóvenes con DM1 entre 5 a 15 años de edad.

METODOLOGÍA:

Se realizó un estudio clínico, observacional, exploratorio. A partir de La recolección de datos de fichas clínicas y muestras de sangre en el Instituto de Investigaciones Materno Infantil (IDIMI) del Hospital San Borja Arriarán de la Universidad de Chile. Clasificación del estado nutricional utilizando datos registrados en ficha clínica. Marcadores de inflamación por medio de ELISA, hemoglobina glicosilada mediante métodos estándares. El análisis estadístico incluyó correlaciones mediante test de Spearman y diferencia de medias mediante test de Kruskal-Wallis seguido de post hoc Dunns.

RESULTADOS:

Un 30% de los pacientes con DM1 presentaron malnutrición por exceso. Al analizar la relación entre los niveles de marcadores inflamatorios y Hb glicosilada se observó la existencia de asociacion positiva entre usPCR y HbA1c (r= 0,30; p=0,0352) y entre IL-6 y HbA1c (r= - 0,038; p=0,0352).

CONCLUSIONES:

este estudio describe una posible asociación entre parámetros clásicos de inflamación con la hemoglobina glicosilada en las categorias de sobrepeso y obesidad en pacientes con DM1.
ABSTRACT
Type 1 diabetes mellitus (T1D) is an autoimmune disease that generates permanent exogenous insulin dependence, accompanied by chronic subclinical inflammation that leads to an elevation of inflammation markers such as tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6).

OBJECTIVE:

To determine the relationship between BMI on markers of inflammation and metabolic control in children and young people with T1D between 5 and 15 years of age.

METHODOLOGY:

A clinical, observational and exploratory study was carried out, based on the collection of data from clinical records and blood samples of children and adolescents with DM1 at the Instituto de Investigaciones Materno Infantil (IDIMI) of the Hospital San Borja Arriarán of the Universidad de Chile. Nutritional status, levels of inflammation markers and glycosylated hemoglobin were determined by standardized methods. Statistical analysis included correlations by Spearman test and mean difference by Kruskal-Wallis test followed by post hoc Dunns test.

RESULTS:

A total of 56 patients with T1D were analyzed, 30% of whom presented excess malnutrition. Those children or adolescents with obesity presented significantly higher usPCR levels compared to underweight patients or patients at risk of malnutrition (p=0.039). In addition, HbA1c levels were determined which were negatively associated with usPCR (r= 0.30; p=0.0352) and IL-6 (r= - 0.038; p=0.0352) levels.

CONCLUSIONS:

This study points out that nutritional status is associated with usPCR levels, in agreement with what is described in the literature and shows a possible association between classical parameters of inflammation with glycosylated hemoglobin in children and adolescents with nutritional diagnosis of overweight or obesity.
Subject(s)

Full text: Available Collection: International databases Database: LILACS Main subject: Glycated Hemoglobin / Biomarkers / Body Mass Index / Diabetes Mellitus, Type 1 Type of study: Observational study Limits: Adolescent / Child / Humans Language: Spanish Journal: Rev. chil. endocrinol. diabetes Journal subject: Endocrinology Year: 2023 Document type: Article Affiliation country: Chile Institution/Affiliation country: Universidad Bernardo O'Higgins/CL / Universidad de Chile/CL
Full text: Available Collection: International databases Database: LILACS Main subject: Glycated Hemoglobin / Biomarkers / Body Mass Index / Diabetes Mellitus, Type 1 Type of study: Observational study Limits: Adolescent / Child / Humans Language: Spanish Journal: Rev. chil. endocrinol. diabetes Journal subject: Endocrinology Year: 2023 Document type: Article Affiliation country: Chile Institution/Affiliation country: Universidad Bernardo O'Higgins/CL / Universidad de Chile/CL
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