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Ameliorating effects of ethanol extract of root bark of Salacia nitida on blood electrolyte and renal perturbations in Plasmodium berghei-infected mice
Nwiloh, Barine Innocent; Uwakwe, Augustine Amadikwa.
Affiliation
  • Nwiloh, Barine Innocent; University of Nigeria. School of General Studies. Natural Sciences Unit. Nsukka. NG
  • Uwakwe, Augustine Amadikwa; University of Port Harcourt. Faculty of Science. Department of Biochemistry. Choba, Port Harcourt. NG
Braz. J. Pharm. Sci. (Online) ; 59: e20229, 2023. tab
Article in English | LILACS | ID: biblio-1439493
Responsible library: BR40.1
Localization: BR40.1
ABSTRACT
Abstract Malaria, a disease of public health concern is a known cause of kidney failure, and dependence on herbal medicines for its treatment is increasing due to the high cost of drugs. So this study is designed to evaluate the ameliorating effect of ethanol extract from Salacia nitida root bark on electrolyte and renal perturbations in Plasmodium berghei-infected mice. Thirty malariainfected mice divided into five groups of six mice each and another group of six uninfected mice were used for the study. 280, 430, and 580 mg/kg of extract were given to infected mice in groups B, C, and D, 4 mg/kg of artesunate given to group E mice, and 4 ml/kg of physiological saline given to group A and uninfected group F mice for five days. Serum Na+, K+, HCO3, Cl-, TB, urea, creatinine, BUN concentrations, and BUN/creatinine ratio were determined using standard methods. Results showed significant increases (p < 0.05) in Na+, K+, and HCO3 and decreases in Cl-, TB, urea, creatinine, BUN, and BUN/creatinine ratio in the infected treated mice in groups B - E. This study showed that ethanol extract of S. nitida root bark is efficient in the treatment of renal disorders and blood electrolyte perturbations
Subject(s)


Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / Neglected Diseases Health problem: Goal 4: Health financing / Malaria Database: LILACS Main subject: Plant Roots / Salacia / Renal Insufficiency / Malaria Type of study: Health economic evaluation Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2023 Document type: Article Affiliation country: Nigeria Institution/Affiliation country: University of Nigeria/NG / University of Port Harcourt/NG

Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / Neglected Diseases Health problem: Goal 4: Health financing / Malaria Database: LILACS Main subject: Plant Roots / Salacia / Renal Insufficiency / Malaria Type of study: Health economic evaluation Limits: Animals Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2023 Document type: Article Affiliation country: Nigeria Institution/Affiliation country: University of Nigeria/NG / University of Port Harcourt/NG
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