Ameliorating effects of ethanol extract of root bark of Salacia nitida on blood electrolyte and renal perturbations in Plasmodium berghei-infected mice
Braz. J. Pharm. Sci. (Online)
; 59: e20229, 2023. tab
Article
in English
| LILACS
| ID: biblio-1439493
Responsible library:
BR40.1
Localization: BR40.1
ABSTRACT
Abstract Malaria, a disease of public health concern is a known cause of kidney failure, and dependence on herbal medicines for its treatment is increasing due to the high cost of drugs. So this study is designed to evaluate the ameliorating effect of ethanol extract from Salacia nitida root bark on electrolyte and renal perturbations in Plasmodium berghei-infected mice. Thirty malariainfected mice divided into five groups of six mice each and another group of six uninfected mice were used for the study. 280, 430, and 580 mg/kg of extract were given to infected mice in groups B, C, and D, 4 mg/kg of artesunate given to group E mice, and 4 ml/kg of physiological saline given to group A and uninfected group F mice for five days. Serum Na+, K+, HCO3, Cl-, TB, urea, creatinine, BUN concentrations, and BUN/creatinine ratio were determined using standard methods. Results showed significant increases (p < 0.05) in Na+, K+, and HCO3 and decreases in Cl-, TB, urea, creatinine, BUN, and BUN/creatinine ratio in the infected treated mice in groups B - E. This study showed that ethanol extract of S. nitida root bark is efficient in the treatment of renal disorders and blood electrolyte perturbations
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
/
Neglected Diseases
Health problem:
Goal 4: Health financing
/
Malaria
Database:
LILACS
Main subject:
Plant Roots
/
Salacia
/
Renal Insufficiency
/
Malaria
Type of study:
Health economic evaluation
Limits:
Animals
Language:
English
Journal:
Braz. J. Pharm. Sci. (Online)
Journal subject:
Farmacologia
/
Teraputica
/
Toxicologia
Year:
2023
Document type:
Article
Affiliation country:
Nigeria
Institution/Affiliation country:
University of Nigeria/NG
/
University of Port Harcourt/NG