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Epoxy-α-lapachone(2,2-Dimethyl-3,4-dihydro-spiro[2H-naphtho[2,3-b]pyran-10,2′-oxirane]-5(10H)-one): a promising molecule to control infections caused by protozoan parasites
Peixoto, Juliana Figueiredo; Oliveira, Adriane da Silva; Oliveira, Luiz Filipe Gonçalves; Silva, Franklin Souza; Alves, Carlos Roberto.
Affiliation
  • Peixoto, Juliana Figueiredo; Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro. BR
  • Oliveira, Adriane da Silva; Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro. BR
  • Oliveira, Luiz Filipe Gonçalves; Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro. BR
  • Silva, Franklin Souza; Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro. BR
  • Alves, Carlos Roberto; Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro. BR
Braz. j. infect. dis ; 27(2): 102743, 2023. tab, graf
Article in English | LILACS-Express | LILACS | ID: biblio-1439697
Responsible library: BR1.1
ABSTRACT
ABSTRACT Natural products and their derivatives have been sources of search and research for new drugs for the treatment of neglected diseases. Naphthoquinones, a special group of quinones, are products of natural metabolites with a wide spectrum of biological activities and represent a group of interesting molecules for new therapeutic propositions. Among these compounds, lapachol stands out as a molecule from the heartwood of Tabebuia sp. whose structural changes resulted in compounds considered promising, such as epoxy-a-lapachone (ELAP). The biological activity of ELAP has been demonstrated, so far, for parasitic protozoa such as Leishmania spp., Trypanosoma cruzi and Plasmodium spp., species causing diseases needing new drug development and adequate health policy. This work gathers in vitro and in vivo studies on these parasites, as well as the toxicity profile, and the probable mechanisms of action elucidated until then. The potential of ELAP-based technology alternatives for a further drug is discussed here.


Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / SDG3 - Health and Well-Being / Neglected Diseases Health problem: Goal 10: Communicable diseases / Target 3.3: End transmission of communicable diseases / Chagas Disease / Malaria / Neglected Diseases / Zoonoses Database: LILACS Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2023 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR

Full text: Available Collection: International databases Health context: Sustainable Health Agenda for the Americas / SDG3 - Health and Well-Being / Neglected Diseases Health problem: Goal 10: Communicable diseases / Target 3.3: End transmission of communicable diseases / Chagas Disease / Malaria / Neglected Diseases / Zoonoses Database: LILACS Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2023 Document type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fundação Oswaldo Cruz/BR
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