Extended criteria donor organ use for heart-lung transplantation in the modern era
Clinics
; 78: 100205, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1439911
Responsible library:
BR1.1
ABSTRACT
Abstract Background:
Demand for donor hearts and lungs exceeds their supply. Extended Criteria Donor (ECD) organs are used to help meet this demand, but their impact on heart-lung transplantation outcomes is poorly characterized. Methods andresults:
The United Network for Organ Sharing was queried for data on adult heart-lung transplantation recipients (n = 447) from 2005‒2021. Recipients were stratified based on whether they received ECD hearts and/or lungs. Morbidity was analyzed using Kruskal-Wallis, chi-square, and Fisher's exact tests. Mortality was analyzed using Kaplan-Meier estimation, log-rank tests and Cox regression. Sixty-five (14.5%) patients received two ECD organs, 134 (30.0%) received only an ECD lung, and 65 (14.5%) only an ECD heart. Recipients of two ECD organs were older, more likely to have diabetes, and more likely transplanted from 2015‒2021 (p < 0.05). Groups did not differ by pre-transplant diagnosis, intensive care unit disposition, life support use, or hemodynam-ics. Group five-year survival rates ranged from 54.5% to 63.2% (p = 0.428). Groups did not differ by 30-day mortality, strokes, graft rejection, or hospital length of stay.Conclusions:
Using ECD hearts and/or lungs for heart-lung transplantation is not associated with increased mortality and is a safe strategy for increasing donor organ supply in this complex patient population.
Full text:
Available
Collection:
International databases
Database:
LILACS
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2023
Document type:
Article
Affiliation country:
United States
Institution/Affiliation country:
University of Pennsylvania/US