A short history of innate immunity
Mem. Inst. Oswaldo Cruz
; 118: e230023, 2023. graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1440669
Responsible library:
BR1.1
ABSTRACT
Innate immunity refers to the mechanisms responsible for the first line of defense against pathogens, cancer cells and toxins. The innate immune system is also responsible for the initial activation of the body's specific immune response (adaptive immunity). Innate immunity was studied and further developed in parallel with adaptive immunity beginning in the first half of the 19th century and has been gaining increasing importance to our understanding of health and disease. In the present overview, we describe the main findings and ideas that contributed to the development of innate immunity as a continually expanding branch of modern immunology. We start with the toxicological studies by Von Haller and Magendie, in the late 18th and early 19th centuries, and continue with the discoveries in invertebrate immunity that supported the discovery and characterization of lipopolysaccharide (LPS) and pattern recognition receptors that led to the development of the pattern recognition and danger theory.
Full text:
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Collection:
International databases
Database:
LILACS
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2023
Document type:
Article
/
Project document
Affiliation country:
Brazil
/
United States
Institution/Affiliation country:
Fundação Oswaldo Cruz-Fiocruz/BR
/
Saint Louis University School of Medicine/US